{"id":"W4290852318","doi":"10.1126/sciimmunol.abn3800","title":"Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with <i>TRAF3</i> mutations","year":2022,"lang":"en","type":"article","venue":"Science Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute on Aging; Medical Research Council; National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust","keywords":"Immunology; Biology; Autoimmunity; B cell; Tumor necrosis factor alpha; Immune system; Immune dysregulation; Cancer research; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341761,0.0007735942,0.0001917889,0.0009401794,0.0004339135,0.0003111105,0.0001671402,0.0005011222,0.002188508],"category_scores_gemma":[0.0002569261,0.000149126,0.000225042,0.0004299757,0.0003675195,0.0001621511,0.0002714769,0.0003328783,0.0001805993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490524,"about_ca_system_score_gemma":0.0001135114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007353132,"about_ca_topic_score_gemma":0.0006204412,"domain_scores_codex":[0.9998902,0.00002479674,0.00001196307,0.00004052539,0.00001913479,0.00001330391],"domain_scores_gemma":[0.9999031,0.00001382902,0.00004629979,0.000008336844,0.000005486144,0.00002296942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001890505,0.0002489589,0.3747536,0.0001700567,0.0003387352,0.03544913,0.0007206798,0.0007326679,0.5465263,0.002665836,0.001545045,0.03495848],"study_design_scores_gemma":[0.0000763306,0.000582875,0.804263,0.00009256363,0.0003534867,0.159787,0.0002656849,0.001223142,0.02499384,0.001719118,0.006597993,0.0000449516],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961201,0.0009142039,0.0009089028,0.0001322368,0.00001068023,0.000008379259,0.0002211884,0.00006076443,0.001623456],"genre_scores_gemma":[0.9977531,0.0004583172,0.0009993056,0.00007722841,0.00001752721,0.000008024707,0.0001645732,0.00001060126,0.000511431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002188508,"threshold_uncertainty_score":0.007321298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005041922715711872,"score_gpt":0.2103082273695319,"score_spread":0.2052663046538201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}