{"id":"W4290927211","doi":"10.1101/gr.276665.122","title":"Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids","year":2022,"lang":"en","type":"article","venue":"Genome Research","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Svenska Sällskapet för Medicinsk Forskning; Emil och Wera Cornells Stiftelse; Vetenskapsrådet; Science for Life Laboratory; European Commission","keywords":"Biology; Blastocyst; Epigenetics; Transcriptome; DNA methylation; Embryo; Inner cell mass; microRNA; Epigenesis; Genetics; Maternal to zygotic transition; Offspring; Zygote; Bioinformatics; Andrology; Embryogenesis; Gene; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638503,0.0001969823,0.0003736602,0.0004289698,0.0002628609,0.0004170074,0.0001454551,0.0002781299,0.001534763],"category_scores_gemma":[0.0002802909,0.0001513011,0.0003019129,0.0005328455,0.0001238161,0.0001387729,0.0002806318,0.0003054264,0.0005746024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001393822,"about_ca_system_score_gemma":0.000222685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001705223,"about_ca_topic_score_gemma":0.002893565,"domain_scores_codex":[0.9998318,0.00001485644,0.00001089107,0.0000658959,0.00005308319,0.00002357836],"domain_scores_gemma":[0.9998897,0.00003663736,0.00002314498,0.00001458342,0.00002727172,0.000008643783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002813227,0.00001294666,0.0209761,0.0003236121,0.0001162952,0.0002772601,0.0002137836,0.0004008363,0.9512103,0.0001685154,0.000989078,0.02502986],"study_design_scores_gemma":[0.0000156699,0.0002786377,0.7073748,0.00009606495,0.0003689721,0.001902699,0.0006151404,0.002919582,0.2555714,0.0007766935,0.03001742,0.00006295367],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9272209,0.01541388,0.01677637,0.0003789095,0.0001059091,0.00006388083,0.03409613,0.0003861637,0.005557857],"genre_scores_gemma":[0.9370333,0.009790866,0.01534271,0.0005157728,0.00005704021,0.0002118143,0.03033085,0.0001810694,0.00653655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705223,"threshold_uncertainty_score":0.005134284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1172680492496297,"score_gpt":0.3586471193692105,"score_spread":0.2413790701195808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}