{"id":"W4290927211","doi":"10.1101/gr.276665.122","title":"Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids","year":2022,"lang":"en","type":"article","venue":"Genome Research","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Svenska Sällskapet för Medicinsk Forskning; Emil och Wera Cornells Stiftelse; Vetenskapsrådet; Science for Life Laboratory; European Commission","keywords":"Biology; Blastocyst; Epigenetics; Transcriptome; DNA methylation; Embryo; Inner cell mass; microRNA; Epigenesis; Genetics; Maternal to zygotic transition; Offspring; Zygote; Bioinformatics; Andrology; Embryogenesis; Gene; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00230897,0.0001178082,0.0002652956,0.0002966342,0.0005911764,0.0000136582,0.0004548149,0.00008676455,0.001502781],"category_scores_gemma":[0.0001235754,0.0001188674,0.00007705393,0.0004219041,0.0001844143,0.000048343,0.0005360704,0.0004834957,0.0003057255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002121901,"about_ca_system_score_gemma":0.0001211647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003284722,"about_ca_topic_score_gemma":0.00007015509,"domain_scores_codex":[0.9968882,0.001462266,0.0004117015,0.0005602215,0.0001609551,0.0005166955],"domain_scores_gemma":[0.9987143,0.0001436117,0.00009371419,0.0007145161,0.0002922119,0.0000416073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001188546,0.0006405241,0.008422339,0.0001141434,0.00003839847,0.000004446345,0.00302901,0.0000603955,0.9859496,0.0001225491,0.0002988998,0.001200863],"study_design_scores_gemma":[0.001720348,0.003345869,0.06513643,0.00001924161,0.00001774888,0.00005873012,0.004283841,0.000001937236,0.914844,0.0002572539,0.01003046,0.0002841101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924014,0.002869952,0.0001540871,0.00006635895,0.0002862579,0.001302777,0.0001815092,0.00003193003,0.002705733],"genre_scores_gemma":[0.9873034,0.000007903071,0.0001285517,0.00001157478,0.00003696363,0.0002015945,0.0001862577,0.00002031285,0.01210341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07110555,"threshold_uncertainty_score":0.99941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1172680492496297,"score_gpt":0.3586471193692105,"score_spread":0.2413790701195808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}