{"id":"W4290958807","doi":"10.6004/jnccn.2022.7033","title":"Association of Polypharmacy and Potentially Inappropriate Medications With Frailty Among Older Adults With Blood Cancers","year":2022,"lang":"en","type":"article","venue":"Journal of the National Comprehensive Cancer Network","topic":"Pharmaceutical Practices and Patient Outcomes","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Dana-Farber/Harvard Cancer Center; National Institute on Aging; National Cancer Institute; National Institutes of Health; Brigham and Women's Hospital; U.S. Department of Veterans Affairs","keywords":"Medicine; Polypharmacy; Odds ratio; Anticholinergic; Odds; Comorbidity; Beers Criteria; Geriatric oncology; Internal medicine; Geriatrics; Cross-sectional study; Cancer; Logistic regression; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000250286,0.0001015469,0.0002519305,0.00006345806,0.0002200182,0.00001019886,0.0001301217,0.00002681179,0.0002023235],"category_scores_gemma":[0.00006149489,0.00006170417,0.00007458175,0.0003733764,0.0000846992,0.0001358359,0.0000675874,0.0005620145,1.23649e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000325979,"about_ca_system_score_gemma":0.0005956599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000719574,"about_ca_topic_score_gemma":0.00002956274,"domain_scores_codex":[0.9979908,0.0001581869,0.0003352712,0.0001095299,0.001263009,0.0001431889],"domain_scores_gemma":[0.9970717,0.0003284817,0.001208287,0.00006372235,0.001227065,0.0001007268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004766491,0.0002835378,0.9023434,0.0001472004,0.003645305,0.00001608837,0.0009672116,0.07588531,0.0004078368,0.0001213561,0.01010926,0.001307021],"study_design_scores_gemma":[0.01163006,0.0007535064,0.9621273,0.0006618321,0.002418344,0.0002393962,0.0005081633,0.003605883,0.0002603915,0.0001447938,0.01747511,0.0001752276],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872792,0.002513516,0.00006581748,0.008959952,0.0004461154,0.0004230472,0.00003578699,0.000005265719,0.0002712822],"genre_scores_gemma":[0.9959837,0.0003872084,0.0004280218,0.002551498,0.0003936641,0.00002070921,0.000004723013,0.00001244423,0.0002180187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07227942,"threshold_uncertainty_score":0.2516223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04049587474737516,"score_gpt":0.3394308472614818,"score_spread":0.2989349725141066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}