{"id":"W4290964008","doi":"10.1016/j.bone.2022.116517","title":"Denosumab treatment is associated with decreased cortical porosity and increased bone density and strength at the proximal humerus of ovariectomized cynomolgus monkeys","year":2022,"lang":"en","type":"article","venue":"Bone","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Alberta Bone and Joint Health Institute","funders":"Amgen","keywords":"Denosumab; Bone mineral; Ovariectomized rat; Osteoporosis; Medicine; Cortical bone; Urology; Bone density; Nuclear medicine; Materials science; Anatomy; Internal medicine; Estrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570289,0.0003171857,0.0006847522,0.001016959,0.0004996008,0.0003864053,0.0002399697,0.0006152435,0.001091329],"category_scores_gemma":[0.0003186572,0.0004059424,0.0004351248,0.0002987809,0.000812528,0.0001977767,0.0002618513,0.0008197746,0.0002583722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003836837,"about_ca_system_score_gemma":0.0003217723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005380184,"about_ca_topic_score_gemma":0.006596046,"domain_scores_codex":[0.9997863,0.00003230658,0.00001209279,0.00004103137,0.00005488929,0.00007337179],"domain_scores_gemma":[0.999703,0.00003988172,0.0001168618,0.00003580078,0.00002200267,0.00008231939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003137476,0.0001621555,0.00208469,0.00004691592,0.00003901157,0.000333285,0.00007150078,0.000101757,0.9917242,0.00008294007,0.0001226743,0.002093435],"study_design_scores_gemma":[0.0005853389,0.006735446,0.2931358,0.00004702808,0.0003455028,0.003406568,0.0006817347,0.002270062,0.6871089,0.0005552399,0.005061079,0.00006727614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998094,0.0007839356,0.0002079133,0.0001260433,0.00001140761,0.000007010352,0.0002626346,0.00002382489,0.0004831638],"genre_scores_gemma":[0.9963976,0.0006397443,0.0002741576,0.0001077168,0.00001254195,0.0000301226,0.000375348,0.00002014305,0.00214265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005380184,"threshold_uncertainty_score":0.01069772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819913565820974,"score_gpt":0.2763283129881444,"score_spread":0.2581291773299346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}