{"id":"W4290994344","doi":"10.1200/jco.22.00597","title":"Smart Start: Rituximab, Lenalidomide, and Ibrutinib in Patients With Newly Diagnosed Large B-Cell Lymphoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"Janssen Biotech; National Cancer Institute; University of Texas MD Anderson Cancer Center; National Institutes of Health; Genentech; Janssen Scientific Affairs; Karyopharm Therapeutics; Conquer Cancer Foundation; Gilead Sciences; Sanofi; MorphoSys; Celgene; AstraZeneca; Bristol-Myers Squibb; American Society of Clinical Oncology; GlaxoSmithKline; Amgen","keywords":"Medicine; Lenalidomide; Ibrutinib; Rituximab; Chemoimmunotherapy; Internal medicine; Chemotherapy; Diffuse large B-cell lymphoma; Oncology; International Prognostic Index; Surgery; Lymphoma; Gastroenterology; Multiple myeloma; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005266212,0.0001699356,0.001602168,0.0002621174,0.00009476714,0.00001335825,0.0002453529,0.0002103967,0.0004332629],"category_scores_gemma":[0.002484872,0.0001234272,0.0002222784,0.0003147409,0.0002417566,0.0001264178,0.0003166148,0.001182248,0.00001734721],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.00488152,"about_ca_system_score_gemma":0.01706017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001420722,"about_ca_topic_score_gemma":0.0001330812,"domain_scores_codex":[0.9951923,0.0009164735,0.002056108,0.0003021152,0.001021106,0.0005118827],"domain_scores_gemma":[0.9943185,0.003488373,0.001054756,0.0002751682,0.0003299925,0.0005332041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.05693795,0.03456409,0.8219319,0.0001182232,0.0003164538,0.00885826,0.0004277977,0.00004473111,0.00001037633,0.00008919722,0.01662089,0.06008011],"study_design_scores_gemma":[0.5057991,0.02571364,0.3509358,0.00006413332,0.0001445168,0.0003617861,0.0002934735,0.0005593795,0.00001209111,0.00009192513,0.1158841,0.0001400525],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994672,0.0004500282,0.00001911111,0.002030506,0.0004903273,0.0004083567,0.00001466948,0.000007839981,0.00190719],"genre_scores_gemma":[0.9949972,0.0002142294,0.001188721,0.002862071,0.0003043578,0.0000137593,0.000009712583,0.00003025418,0.0003797172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4709961,"threshold_uncertainty_score":0.9989386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04737117210037393,"score_gpt":0.3881505520512346,"score_spread":0.3407793799508607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}