{"id":"W4291016626","doi":"10.3390/cancers14163877","title":"Development of Olaparib-Resistance Prostate Cancer Cell Lines to Identify Mechanisms Associated with Acquired Resistance","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Urological Association","keywords":"Olaparib; DU145; Cancer research; LNCaP; Biology; Prostate cancer; DNA repair; Cancer; Medicine; Poly ADP ribose polymerase; Gene; Genetics; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686629,0.0004180566,0.0004523816,0.000609783,0.0002070308,0.0003780159,0.0003047187,0.0002436643,0.001636248],"category_scores_gemma":[0.0001615366,0.0001466765,0.0003814512,0.0008709689,0.0001729119,0.0001851336,0.0001877409,0.0007042734,0.0007280646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002651299,"about_ca_system_score_gemma":0.0002521538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009093024,"about_ca_topic_score_gemma":0.001219293,"domain_scores_codex":[0.9996251,0.00003621596,0.000043177,0.00009319012,0.0001443864,0.00005787719],"domain_scores_gemma":[0.9998143,0.00003673133,0.00003695494,0.00003341939,0.00005521624,0.00002338699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224461,0.0001127745,0.001192473,0.0001292507,0.00001872252,0.00008251103,0.00003574331,0.0002150719,0.9948461,0.00009879534,0.0002808846,0.002865236],"study_design_scores_gemma":[0.00003871903,0.0009795027,0.02574426,0.00002184425,0.0001296814,0.0009305106,0.0001438237,0.004633084,0.9567986,0.0001181097,0.010433,0.00002901257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511798,0.003793431,0.02578469,0.0002694589,0.0001103358,0.0007054418,0.01306389,0.000630701,0.00446226],"genre_scores_gemma":[0.9267703,0.004101946,0.03137016,0.00037334,0.00003893765,0.0011262,0.0294331,0.0001256446,0.006660399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001636248,"threshold_uncertainty_score":0.005473733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0249911659043297,"score_gpt":0.3081018750259518,"score_spread":0.2831107091216221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}