{"id":"W4291019066","doi":"10.1136/thoraxjnl-2021-218194","title":"Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis","year":2022,"lang":"en","type":"article","venue":"Thorax","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hjärt-Lungfonden; Medical Research Council; Public Health Agency; Queen's University Belfast; Alfred Österlunds Stiftelse; Invest Northern Ireland; Queen's University; Wellcome Trust","keywords":"Mesenchymal stem cell; Tensin; Tumor necrosis factor alpha; ARDS; PTEN; Stromal cell; Medicine; Cancer research; Inflammation; Cell biology; Suppressor of cytokine signaling 1; Immunology; Biology; Signal transduction; Lung; PI3K/AKT/mTOR pathway; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002995587,0.0003452782,0.0003938913,0.0002904149,0.0001212356,0.000348029,0.0001486505,0.0002883608,0.001082654],"category_scores_gemma":[0.0001389654,0.0001248005,0.0004084802,0.000141842,0.000390082,0.0002482467,0.000275138,0.0005944499,0.0003229213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662796,"about_ca_system_score_gemma":0.0002367267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001039799,"about_ca_topic_score_gemma":0.0001652792,"domain_scores_codex":[0.9997556,0.00004825178,0.00002988841,0.00003615532,0.00007705409,0.00005297218],"domain_scores_gemma":[0.9999037,0.00001201868,0.00003845597,0.000009401007,0.00001106036,0.00002528953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003736827,0.00006573943,0.0003796705,0.0001710136,0.00001380376,0.00009137067,0.00002065768,0.00009524952,0.9958675,0.0002149568,0.00009072717,0.002615686],"study_design_scores_gemma":[0.00008266141,0.001375726,0.004577563,0.0000220238,0.00006410908,0.0005703055,0.00005739236,0.001125605,0.986982,0.0001498737,0.004983664,0.000009040214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825017,0.005304026,0.008724752,0.0003634676,0.0002198753,0.0001449482,0.0007119522,0.0002508778,0.001778409],"genre_scores_gemma":[0.9921592,0.002024822,0.003598461,0.0001259593,0.00004622689,0.0001218852,0.000555588,0.00002533674,0.001342552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082654,"threshold_uncertainty_score":0.003621876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966539746116089,"score_gpt":0.2636683648736281,"score_spread":0.2440029674124672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}