{"id":"W4291019342","doi":"10.1038/s41467-022-32149-8","title":"Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services","keywords":"Virology; Vaccination; Virus; Antigen; Influenza vaccine; Biology; Messenger RNA; Nucleoside; Antigenic variation; Immune system; Antigenic drift; Influenza A virus; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204214,0.0001958096,0.0001668223,0.00008319204,0.00007579988,0.0001688882,0.0001240988,0.0002059607,0.0005818684],"category_scores_gemma":[0.0001204169,0.00008351547,0.0001095238,0.00005056557,0.0001269002,0.0001750685,0.0001719754,0.0002916936,0.0001425665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000153127,"about_ca_system_score_gemma":0.0002252239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001969708,"about_ca_topic_score_gemma":0.0003066527,"domain_scores_codex":[0.999939,0.000009267799,0.000005114583,0.00001352434,0.0000224439,0.00001069992],"domain_scores_gemma":[0.9999654,0.000006078237,0.00001042809,0.000003535619,0.000005863478,0.00000870541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002597768,0.00001669543,0.00007575664,0.00003355697,0.00000235071,0.00002606264,0.000007678736,0.0002381727,0.9957313,0.0001292423,0.0000238983,0.003689351],"study_design_scores_gemma":[0.0000144495,0.0006105765,0.0005228611,0.000005953831,0.00001087547,0.0001213525,0.00001020949,0.001315984,0.9946247,0.00005375804,0.002706356,0.000002939206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722183,0.002122575,0.02255489,0.0001767763,0.00005026533,0.0001485501,0.0001176366,0.0001021493,0.002508704],"genre_scores_gemma":[0.965956,0.001715758,0.02948539,0.0000829136,0.00001519328,0.00008902791,0.0002616184,0.0000184403,0.002375631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005818684,"threshold_uncertainty_score":0.001946509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1189664415693295,"score_gpt":0.4174902218459139,"score_spread":0.2985237802765844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}