{"id":"W4291020055","doi":"10.1126/sciimmunol.abn6373","title":"Cis interactions between CD2 and its ligands on T cells are required for T cell activation","year":2022,"lang":"en","type":"article","venue":"Science Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Agence Nationale de la Recherche","keywords":"T-cell receptor; T cell; Cell biology; ZAP70; Antigen-presenting cell; Cytotoxic T cell; Biology; Cytotoxicity; Molecular biology; Chemistry; Biochemistry; In vitro; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221459,0.00074274,0.0004432278,0.0002763199,0.0003237555,0.0008847197,0.000301451,0.0005529276,0.003150533],"category_scores_gemma":[0.0003464938,0.0002497252,0.0002920252,0.0002030619,0.0003141713,0.0005846833,0.000676289,0.0009749733,0.002124323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003939671,"about_ca_system_score_gemma":0.0002663704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002197832,"about_ca_topic_score_gemma":0.000340215,"domain_scores_codex":[0.999363,0.00008082612,0.00004532283,0.0001986856,0.0001691227,0.0001430803],"domain_scores_gemma":[0.9995603,0.00004876552,0.0001217066,0.00005192885,0.00007008413,0.0001472746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005656076,0.00001168344,0.000253739,0.00003309792,0.000003382753,0.0001176213,0.00001025426,0.00003172305,0.9983935,0.0001430105,0.00007899583,0.0008665055],"study_design_scores_gemma":[0.00002080313,0.0001198769,0.007512852,0.00001499538,0.00002103286,0.001186719,0.00006474611,0.0009442708,0.9832916,0.0002252151,0.00658843,0.000009617907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965524,0.006018788,0.01989702,0.0003605591,0.0001822796,0.00004774268,0.0008174247,0.0005673719,0.006584725],"genre_scores_gemma":[0.9900244,0.0009601965,0.003238539,0.0001296942,0.0000437567,0.00005164332,0.0009447566,0.0000997032,0.004507184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003150533,"threshold_uncertainty_score":0.01053953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02534943912788355,"score_gpt":0.269097592702025,"score_spread":0.2437481535741415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}