{"id":"W4291020647","doi":"10.1038/s41380-022-01716-2","title":"Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministério da Ciência, Tecnologia e Inovação; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Government of Canada; EU Joint Programme – Neurodegenerative Disease Research; National Alliance for Research on Schizophrenia and Depression; Alzheimerfonden; Weston Brain Institute; International Society for Neurochemistry; U.S. Department of Health and Human Services; Gun och Bertil Stohnes Stiftelse; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Cerveau Technologies; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Demensförbundet; McGill University; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Astrogliosis; Glial fibrillary acidic protein; Biomarker; Cerebrospinal fluid; Astrocyte; Pathology; Alzheimer's disease; Neuroscience; Amyloid (mycology); Senile plaques; Positron emission tomography; Amyloid beta; Medicine; Psychology; Biology; Disease; Central nervous system; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003270105,0.000252931,0.0003197537,0.0007289029,0.0002526671,0.0004631114,0.00009389351,0.0001887339,0.0004709934],"category_scores_gemma":[0.0005391106,0.0001350642,0.0001798669,0.0004518961,0.0001833026,0.0001868344,0.0002652581,0.0001438609,0.00009655509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001414743,"about_ca_system_score_gemma":0.0001241904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00223975,"about_ca_topic_score_gemma":0.00282254,"domain_scores_codex":[0.9998777,0.00003492537,0.00001834064,0.00002173605,0.00003261319,0.00001461628],"domain_scores_gemma":[0.9997119,0.00003176761,0.0001293074,0.00001727676,0.000074805,0.000034826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0010634,0.00007616775,0.9605992,0.00004501413,0.0001480038,0.0003760207,0.0003054487,0.000259839,0.03013533,0.00008008291,0.00009134493,0.006820225],"study_design_scores_gemma":[0.000009297036,0.0001728075,0.9949722,0.000006609256,0.00005298022,0.0009084517,0.0002605056,0.0005353336,0.002730393,0.0001783874,0.0001678158,0.000005222481],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999499,0.0001618053,0.0001150668,0.000007451607,0.000001275761,0.000002928027,0.00005843579,0.000002175858,0.0001519398],"genre_scores_gemma":[0.9996291,0.00007181617,0.000150156,0.000005040031,0.000001563108,0.00000249905,0.00006298188,7.773329e-7,0.00007604225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00223975,"threshold_uncertainty_score":0.00445348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807734490097757,"score_gpt":0.3002183984465268,"score_spread":0.2821410535455492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}