{"id":"W4291020647","doi":"10.1038/s41380-022-01716-2","title":"Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministério da Ciência, Tecnologia e Inovação; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Government of Canada; EU Joint Programme – Neurodegenerative Disease Research; National Alliance for Research on Schizophrenia and Depression; Alzheimerfonden; Weston Brain Institute; International Society for Neurochemistry; U.S. Department of Health and Human Services; Gun och Bertil Stohnes Stiftelse; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Cerveau Technologies; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Demensförbundet; McGill University; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Astrogliosis; Glial fibrillary acidic protein; Biomarker; Cerebrospinal fluid; Astrocyte; Pathology; Alzheimer's disease; Neuroscience; Amyloid (mycology); Senile plaques; Positron emission tomography; Amyloid beta; Medicine; Psychology; Biology; Disease; Central nervous system; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291093,0.0001580704,0.0002394964,0.0002298124,0.00008020341,0.00000869391,0.00009119562,0.00003174087,0.0001277024],"category_scores_gemma":[0.00002706305,0.0001428724,0.0001249723,0.00026959,0.0001182964,0.00003538782,0.0001752804,0.0002335094,0.000003824008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002837045,"about_ca_system_score_gemma":0.0002982339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002961606,"about_ca_topic_score_gemma":0.000003216749,"domain_scores_codex":[0.9986185,0.0001439414,0.0002092943,0.0003249312,0.0004163764,0.0002869242],"domain_scores_gemma":[0.9993024,0.00001910912,0.00006398329,0.0003285709,0.00002847414,0.0002574071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00451403,0.00347787,0.9700463,0.0001903098,0.004884316,0.004545217,0.0001178201,0.00009276081,0.003528954,0.001337671,0.002293709,0.004971057],"study_design_scores_gemma":[0.003917631,0.0007187149,0.9909407,0.0000631289,0.0007793145,0.00005999115,0.0004264956,0.000156009,0.000654149,0.001836646,0.0002408087,0.0002063654],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8773261,0.120288,0.00001794413,0.001346008,0.0001052326,0.000452766,0.0001055574,0.00003007534,0.000328325],"genre_scores_gemma":[0.998454,0.0001079174,0.0008042413,0.0003724273,0.0000140152,0.000116955,0.00009825837,0.00002468687,0.00000749388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1211279,"threshold_uncertainty_score":0.5826169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807734490097757,"score_gpt":0.3002183984465268,"score_spread":0.2821410535455492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}