{"id":"W4291129543","doi":"10.1002/bit.28210","title":"Challenges and opportunities in downstream separation processes for mesenchymal stromal cells cultured in microcarrier‐based stirred suspension bioreactors","year":2022,"lang":"en","type":"review","venue":"Biotechnology and Bioengineering","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Microcarrier; Mesenchymal stem cell; Bioreactor; Downstream (manufacturing); Downstream processing; Suspension culture; Cell biology; Biochemical engineering; Cell culture; Regenerative medicine; Filtration (mathematics); Stromal cell; Biotechnology; Process engineering; Materials science; Chemistry; Cell; Stem cell; Biology; Chromatography; Engineering; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003739415,0.0004168376,0.001183826,0.0009069081,0.00005878614,0.00001994467,0.0001325621,0.0009459201,0.00001092693],"category_scores_gemma":[0.0001734717,0.0003445233,0.00008093258,0.0003864038,0.0001885519,0.00006257997,0.0001313663,0.0006863737,4.345887e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681275,"about_ca_system_score_gemma":0.0002738729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002018628,"about_ca_topic_score_gemma":0.0001200191,"domain_scores_codex":[0.9982448,0.00005686015,0.0004856153,0.0006092008,0.0001557748,0.0004477248],"domain_scores_gemma":[0.999182,0.0003202506,0.0001247937,0.0002345063,0.00003194503,0.0001064843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001193656,0.0001491165,0.00003502977,0.0483796,0.00009881298,0.0002247312,0.0001260426,0.000004690114,0.005366167,0.000202505,0.00003235509,0.9452616],"study_design_scores_gemma":[0.001535822,0.001055005,0.000105102,0.007850088,0.0002675464,0.0002555271,0.0007192563,0.0004362762,0.005248449,0.000009880772,0.9818844,0.0006326143],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005846314,0.9914399,0.00001975454,0.0007250726,0.00008844671,0.001676535,0.00006174335,0.0001033193,0.00003889597],"genre_scores_gemma":[0.009374562,0.9894537,0.0004918149,0.000007429042,0.00003989572,0.0003177539,0.0002187251,0.00004224306,0.00005384564],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9818521,"threshold_uncertainty_score":0.9999007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1628504745632842,"score_gpt":0.3591388734303615,"score_spread":0.1962883988670773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}