{"id":"W4291142685","doi":"10.3389/fncel.2022.932572","title":"All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer’s disease","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia; Université Laval; University of Victoria","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Microglia; Neuroscience; Pathogenesis; Biology; Amyloid beta; Senile plaques; Alzheimer's disease; Disease; Cerebral amyloid angiopathy; Neurite; Neurodegeneration; Amyloid (mycology); Pathology; Medicine; Dementia; Immunology; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000748126,0.000448846,0.0009977586,0.001170618,0.0003818263,0.001984762,0.0004595518,0.0008654885,0.001434286],"category_scores_gemma":[0.0007287505,0.0001663494,0.0005135589,0.001223971,0.000970502,0.001940795,0.001010941,0.001705319,0.0006953772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006869134,"about_ca_system_score_gemma":0.001038096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008452938,"about_ca_topic_score_gemma":0.001116518,"domain_scores_codex":[0.9996302,0.00008179364,0.00005415678,0.00008071276,0.0001018607,0.00005133082],"domain_scores_gemma":[0.9995253,0.000217167,0.00007815819,0.00001443635,0.0001170446,0.00004797466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002775748,0.00004484713,0.002650441,0.0192581,0.0003514349,0.002171302,0.001499844,0.0004591072,0.02309056,0.02591525,0.04417907,0.8801024],"study_design_scores_gemma":[0.00001269683,0.0001521195,0.006368276,0.003259506,0.0003052593,0.005511446,0.001061039,0.0001594716,0.003637529,0.01698765,0.9624853,0.00005966445],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001016126,0.9949253,0.0004271864,0.001924612,0.0004854714,0.000004244343,0.00003102855,0.00001443755,0.001171581],"genre_scores_gemma":[0.009127347,0.9869031,0.0005703014,0.00130406,0.001208006,0.000009652707,0.00005034553,0.000006120521,0.000821193],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001984762,"threshold_uncertainty_score":0.004983902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1613596080780713,"score_gpt":0.3228360686586081,"score_spread":0.1614764605805368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}