{"id":"W4291146071","doi":"10.1161/circresaha.121.320717","title":"Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury","year":2022,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institute for Health and Care Research; Barts Charity; British Heart Foundation; Wellcome Trust","keywords":"Malonate; Ischemia; Pharmacology; In vivo; Reperfusion injury; Chemistry; Myocyte; Biochemistry; Medicine; Anesthesia; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000231128,0.0007610839,0.00039782,0.0003344817,0.0001459601,0.0004211907,0.0002789664,0.0003902622,0.001605896],"category_scores_gemma":[0.0001171308,0.0001377196,0.0004747343,0.0001962713,0.0002854681,0.0003647573,0.000308413,0.0005527022,0.000388596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003283957,"about_ca_system_score_gemma":0.0004621826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000436245,"about_ca_topic_score_gemma":0.001053325,"domain_scores_codex":[0.9998677,0.00002207977,0.00001354156,0.00002694396,0.00003193021,0.00003777077],"domain_scores_gemma":[0.9999044,0.000009267426,0.00003496756,0.00001003885,0.00001650224,0.00002495406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002765056,0.00001849313,0.00009180128,0.00006754957,0.000005699514,0.00001827011,0.000003615424,0.00002487044,0.9982914,0.00003682216,0.00003017283,0.001134855],"study_design_scores_gemma":[0.00003551172,0.0006445698,0.002043717,0.000011546,0.00002966467,0.0001284733,0.00001121152,0.0002451924,0.9958191,0.00002168584,0.001004716,0.000004532635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644618,0.01814842,0.01267441,0.000507962,0.0001527021,0.0001271502,0.001026052,0.0003866285,0.002514778],"genre_scores_gemma":[0.9873872,0.005217828,0.004643354,0.0001716659,0.00003357116,0.00005929632,0.0008228857,0.00003275238,0.001631382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001605896,"threshold_uncertainty_score":0.005372286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03837131655108286,"score_gpt":0.3627521988465902,"score_spread":0.3243808822955073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}