{"id":"W4291146071","doi":"10.1161/circresaha.121.320717","title":"Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury","year":2022,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institute for Health and Care Research; Barts Charity; British Heart Foundation; Wellcome Trust","keywords":"Malonate; Ischemia; Pharmacology; In vivo; Reperfusion injury; Chemistry; Myocyte; Biochemistry; Medicine; Anesthesia; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002012805,0.0001608177,0.0003023839,0.0003408396,0.001167079,0.00003832252,0.0001141583,0.000175637,0.0004212898],"category_scores_gemma":[0.0003713673,0.0001620151,0.0002866739,0.0009702631,0.00009355288,0.000107439,0.0002271674,0.001016759,0.00002802941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008399122,"about_ca_system_score_gemma":0.0003195587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001778653,"about_ca_topic_score_gemma":0.000001055056,"domain_scores_codex":[0.9970696,0.000208689,0.0002966595,0.0006114321,0.001314641,0.0004989895],"domain_scores_gemma":[0.9984618,0.0001541713,0.00007399479,0.0004315464,0.0007077086,0.000170736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005704933,0.0001135722,0.004127766,0.00009350195,0.00005560579,0.000005634204,0.000216798,0.0002143758,0.918521,0.00002913708,0.05808017,0.01797193],"study_design_scores_gemma":[0.001972106,0.0004747073,0.0006144872,0.00003377731,0.0000566926,0.0001667764,0.0006302472,0.006392164,0.921922,0.0001392035,0.06735178,0.000246073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864171,0.000556227,0.001443417,0.001230061,0.0002639176,0.002172774,0.00006536439,0.0001102037,0.007740979],"genre_scores_gemma":[0.9934515,0.0000405979,0.00009252507,0.0001055468,0.0003596375,0.001334234,0.0004488403,0.00005509014,0.004112044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01772585,"threshold_uncertainty_score":0.8976344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03837131655108286,"score_gpt":0.3627521988465902,"score_spread":0.3243808822955073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}