{"id":"W4291146243","doi":"10.1097/shk.0000000000001972","title":"DNASE-MEDIATED DISSOLUTION OF NEUTROPHIL EXTRACELLULAR TRAPS ACCELERATES IN VITRO THROMBIN GENERATION KINETICS IN TRAUMA PATIENTS","year":2022,"lang":"en","type":"article","venue":"Shock","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Neutrophil extracellular traps; Thrombin; Thrombin generation; Andrology; Chemistry; Molecular biology; Liter; Deoxyribonuclease I; In vitro; Internal medicine; Medicine; Endocrinology; DNA; Inflammation; Biology; Biochemistry; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496318,0.0001971672,0.0003182707,0.0001138661,0.00008185927,0.0003271648,0.00008788139,0.0001790099,0.001901323],"category_scores_gemma":[0.0008317525,0.0001042086,0.000165543,0.0001110536,0.0001132235,0.0001169894,0.0001338378,0.0002786666,0.0003089434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538831,"about_ca_system_score_gemma":0.0001222702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001741754,"about_ca_topic_score_gemma":0.0001441033,"domain_scores_codex":[0.9998728,0.00003749529,0.00001698634,0.00002971348,0.00002144088,0.00002144975],"domain_scores_gemma":[0.999712,0.00007679148,0.0001188743,0.00001610867,0.00002074071,0.00005548221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03427333,0.001002151,0.3315014,0.0004579258,0.0002853835,0.002044785,0.0003749168,0.0007603826,0.5732709,0.0001662615,0.001249999,0.05461252],"study_design_scores_gemma":[0.0009077136,0.02656922,0.7488878,0.00006131392,0.0002615496,0.01359206,0.0002566096,0.003742329,0.2029678,0.0001313132,0.002586858,0.00003553871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986396,0.0007779679,0.0003302515,0.00002480856,0.00000780813,0.00001152761,0.0000782152,0.000009963825,0.0001197311],"genre_scores_gemma":[0.999202,0.0001848851,0.0002438006,0.00003022614,0.00001220487,0.0000107172,0.0001479905,0.000002052048,0.0001663063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001901323,"threshold_uncertainty_score":0.00636059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02050900835825504,"score_gpt":0.2248995399553158,"score_spread":0.2043905315970607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}