{"id":"W4291146243","doi":"10.1097/shk.0000000000001972","title":"DNASE-MEDIATED DISSOLUTION OF NEUTROPHIL EXTRACELLULAR TRAPS ACCELERATES IN VITRO THROMBIN GENERATION KINETICS IN TRAUMA PATIENTS","year":2022,"lang":"en","type":"article","venue":"Shock","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Neutrophil extracellular traps; Thrombin; Thrombin generation; Andrology; Chemistry; Molecular biology; Liter; Deoxyribonuclease I; In vitro; Internal medicine; Medicine; Endocrinology; DNA; Inflammation; Biology; Biochemistry; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196147,0.0001851459,0.0003196207,0.0002742871,0.0001041012,0.00000704201,0.0001954935,0.0001291315,0.0004805661],"category_scores_gemma":[0.00002581977,0.0001906234,0.00006452292,0.0004129027,0.00006841773,0.00009903537,0.00009087053,0.0003716432,0.00002676968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413732,"about_ca_system_score_gemma":0.0000307831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001090027,"about_ca_topic_score_gemma":0.00007839991,"domain_scores_codex":[0.9983143,0.0004465751,0.0004953503,0.0003319396,0.00007722248,0.0003345672],"domain_scores_gemma":[0.9995344,0.00005014964,0.0001479632,0.0002014718,0.00004784247,0.00001818913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002737958,0.0007932236,0.0008390914,0.000009660618,0.00002044762,0.00001044997,0.0004668379,0.0002044484,0.9941741,0.0002533901,0.0001591882,0.002795374],"study_design_scores_gemma":[0.002779659,0.0005986164,0.0186443,0.000008776417,0.00001321808,0.000004447408,0.0002299669,0.0001861885,0.9761707,0.0001864387,0.0009854441,0.0001922889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977074,0.0009756379,0.00008389352,0.0001194082,0.0004527898,0.0004135404,0.00016182,0.00002218883,0.00006337239],"genre_scores_gemma":[0.9975095,0.00004112546,0.0000792483,0.00006943587,0.00001967785,0.00005876219,0.002043551,0.0000219218,0.0001568253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01800344,"threshold_uncertainty_score":0.7773396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02050900835825504,"score_gpt":0.2248995399553158,"score_spread":0.2043905315970607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}