{"id":"W4291155695","doi":"10.3389/fcvm.2022.967659","title":"Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cardiovascular Medicine","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital; Simon Fraser University","funders":"Canadian Institutes of Health Research; Stem Cell Network","keywords":"Induced pluripotent stem cell; Neuroscience; Bioinformatics; Medicine; PI3K/AKT/mTOR pathway; Stem cell; Biology; Embryonic stem cell; Signal transduction; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005708239,0.0003716775,0.0003731142,0.0004446191,0.0001570127,0.0005132424,0.0002703106,0.0005250679,0.00125991],"category_scores_gemma":[0.0003378879,0.0001250832,0.0004247613,0.0004441648,0.000317382,0.0007317488,0.0004135033,0.001244424,0.0005077012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797785,"about_ca_system_score_gemma":0.0004123081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002802243,"about_ca_topic_score_gemma":0.0004315682,"domain_scores_codex":[0.9998075,0.00003409334,0.00002680339,0.00004233176,0.00006824591,0.00002094899],"domain_scores_gemma":[0.9998876,0.00004056314,0.00002553703,0.00001088188,0.00002556685,0.000009905514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001368993,0.0000641844,0.001771041,0.00828568,0.000110504,0.0007003965,0.0002529259,0.001435546,0.7098662,0.02045776,0.005967379,0.2509515],"study_design_scores_gemma":[0.00003690669,0.001055989,0.008817401,0.001657632,0.0004161126,0.003188487,0.000342713,0.002580338,0.4122231,0.01460893,0.554995,0.00007735669],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04240843,0.8587548,0.07429299,0.004202919,0.002087318,0.0002808236,0.001761912,0.000341567,0.01586931],"genre_scores_gemma":[0.2055816,0.7418226,0.03871709,0.003721865,0.001018946,0.0002786867,0.002391571,0.00005614826,0.006411577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00125991,"threshold_uncertainty_score":0.004214883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07540864988520343,"score_gpt":0.3168205554435022,"score_spread":0.2414119055582988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}