{"id":"W4291187460","doi":"10.1136/annrheumdis-2022-eular.2265","title":"OP0255 BIMEKIZUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND AN INADEQUATE RESPONSE TO TUMOUR NECROSIS FACTOR INHIBITORS: 16-WEEK EFFICACY & SAFETY FROM BE COMPLETE, A PHASE 3, MULTICENTRE, RANDOMISED PLACEBO-CONTROLLED STUDY","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Krembil Foundation; Arthritis Society; University of Toronto","funders":"UCB Pharma","keywords":"Medicine; Psoriatic arthritis; Placebo; Internal medicine; Arthritis; Physical therapy; Randomized controlled trial; Necrosis; Surgery; Psoriasis; Alternative medicine; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002216223,0.001761821,0.003534711,0.0005005169,0.0005059378,0.001245413,0.0009041305,0.002136466,0.004719458],"category_scores_gemma":[0.001720413,0.0009462621,0.002386139,0.0004575863,0.001203879,0.001378716,0.0005075466,0.00302755,0.001066354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006356121,"about_ca_system_score_gemma":0.0009763216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007448224,"about_ca_topic_score_gemma":0.001331158,"domain_scores_codex":[0.9992186,0.0003546211,0.00006229266,0.0001272321,0.0000819402,0.0001553564],"domain_scores_gemma":[0.998848,0.0002890113,0.0002896238,0.0001030826,0.00006005882,0.0004103653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9704794,0.007111617,0.001494635,0.0004901246,0.0007671118,0.00006257978,0.00005455204,0.000210812,0.003343099,0.00003716814,0.0004371864,0.0155116],"study_design_scores_gemma":[0.9021174,0.09114069,0.005417382,0.00002343135,0.0003665528,0.00005261386,0.00002261291,0.0001934296,0.0002871024,0.00005018405,0.0003129008,0.00001555622],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993369,0.00348446,0.0002509294,0.0003006614,0.0002008962,0.0009932424,0.0004346974,0.00006103368,0.0009051116],"genre_scores_gemma":[0.9930403,0.001794801,0.0006741325,0.0007469055,0.0004455181,0.00102264,0.0006694145,0.0000161708,0.001590221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004719458,"threshold_uncertainty_score":0.0157882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03223480344019919,"score_gpt":0.3141635530135369,"score_spread":0.2819287495733377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}