{"id":"W4291201940","doi":"10.1186/s12864-022-08811-2","title":"Mendelian randomization of circulating proteome identifies actionable targets in heart failure","year":2022,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Canadian Institutes of Health Research; Université Laval","keywords":"Mendelian randomization; Proteome; Biology; Heart failure; Genome-wide association study; Bioinformatics; Disease; Genetics; Computational biology; Internal medicine; Medicine; Single-nucleotide polymorphism; Gene; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004637525,0.0004260104,0.0006501823,0.001013687,0.0002393592,0.0005010613,0.0004815405,0.0003821877,0.001745067],"category_scores_gemma":[0.00797575,0.0002011073,0.0008139284,0.0006915939,0.0005856086,0.0003051988,0.000516989,0.0003879207,0.0001161803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002233538,"about_ca_system_score_gemma":0.0002987888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004984242,"about_ca_topic_score_gemma":0.0004143,"domain_scores_codex":[0.9968201,0.001644311,0.0001299,0.0009232631,0.00029588,0.000186602],"domain_scores_gemma":[0.9949393,0.003099845,0.001019125,0.0006790906,0.0001162762,0.0001463396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007191454,0.0004054508,0.7278422,0.000370999,0.003705059,0.002335081,0.0004400792,0.01181298,0.1589319,0.01005506,0.000982392,0.07592745],"study_design_scores_gemma":[0.0004749067,0.001988698,0.8522291,0.00003561527,0.002099584,0.003255355,0.0001835879,0.1006971,0.02065371,0.01637126,0.001922497,0.00008859025],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667199,0.0002794632,0.03200117,0.00009396399,0.0000150229,0.00004723491,0.0003209147,0.0001820938,0.0003404061],"genre_scores_gemma":[0.992153,0.00004992999,0.007425979,0.00004780236,0.000008795701,0.00003797234,0.0001689403,0.00002110963,0.00008645032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004637525,"threshold_uncertainty_score":0.02452588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331095018325398,"score_gpt":0.2454028117082774,"score_spread":0.2320918615250234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}