{"id":"W4291222009","doi":"10.1038/s41467-022-32509-4","title":"Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Schweizerischen Gesellschaft für Endokrinologie und Diabetologie; University of Toronto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universität Basel; University of Connecticut; AstraZeneca; Amylin Pharmaceuticals; Universität Zürich; University of Texas Southwestern Medical Center; National Science Foundation","keywords":"Proinsulin; Prohormone convertase; Endocrinology; Internal medicine; Prohormone; Amylin; Impaired glucose tolerance; Prediabetes; Insulin; Medicine; Diabetes mellitus; Obesity; Islet; Biology; Type 2 diabetes; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123892,0.0009142429,0.0002606378,0.0006700599,0.000201266,0.000279273,0.0002865479,0.000476826,0.001784901],"category_scores_gemma":[0.0001524928,0.0002549952,0.0003354764,0.0003508299,0.0004551903,0.000152509,0.0003035421,0.0007263006,0.0005690313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331912,"about_ca_system_score_gemma":0.0002268811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004404009,"about_ca_topic_score_gemma":0.0005448384,"domain_scores_codex":[0.9998341,0.0000238464,0.00002241252,0.00004484567,0.00004102946,0.00003386101],"domain_scores_gemma":[0.9997693,0.00003684134,0.00008710491,0.00002174336,0.000007161615,0.00007783722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007933767,0.0001171687,0.001535405,0.00007484057,0.00001967938,0.001281859,0.00002455605,0.00008757228,0.9930882,0.0001608664,0.0001572163,0.002659297],"study_design_scores_gemma":[0.0002516318,0.0009749988,0.05147823,0.00003313053,0.000130245,0.01244442,0.00006150381,0.001007528,0.927303,0.0003203904,0.005968745,0.00002627849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952513,0.001013127,0.001575106,0.0001290205,0.00004811031,0.0000449736,0.0007621353,0.0001296265,0.001046509],"genre_scores_gemma":[0.9930158,0.001449623,0.001990403,0.00009474038,0.00002559007,0.00005323559,0.001093085,0.00005824414,0.002219381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784901,"threshold_uncertainty_score":0.005971074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02500008944335319,"score_gpt":0.3022340645490356,"score_spread":0.2772339751056824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}