{"id":"W4291222654","doi":"10.1038/s41467-022-31820-4","title":"XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Cancer Institute; National Institutes of Health; Oncode Institute; Natural Sciences and Engineering Research Council of Canada; Leids Universitair Medisch Centrum; KWF Kankerbestrijding; Deutsche Forschungsgemeinschaft; Université Laval; Israel Cancer Association; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Israel Cancer Research Fund","keywords":"Chromatin; DNA damage; DNA; Cell biology; Polymerase; DNA repair; PARP1; Biology; Poly ADP ribose polymerase; Nucleotide excision repair; Chromatin remodeling; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002193274,0.0005305671,0.000252494,0.0002012585,0.0002992133,0.0009483069,0.0003097801,0.0005740594,0.003726719],"category_scores_gemma":[0.0001962854,0.0003284699,0.0002889197,0.0001758891,0.0002932104,0.000757977,0.0008327164,0.0006078097,0.002008898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003899088,"about_ca_system_score_gemma":0.0001262118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001999582,"about_ca_topic_score_gemma":0.0003028172,"domain_scores_codex":[0.9996824,0.00003344227,0.00001510905,0.0001235894,0.00008973117,0.00005570749],"domain_scores_gemma":[0.9998026,0.00001930992,0.00006285106,0.00003858113,0.0000226824,0.00005398861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007223058,0.00001539692,0.000917043,0.00004244642,0.00001079157,0.0001128112,0.00001648683,0.0001205963,0.9953128,0.0002890519,0.0001875891,0.002902633],"study_design_scores_gemma":[0.000009806015,0.0001298615,0.01135218,0.000005874456,0.000008315608,0.0004477562,0.00003407998,0.001172503,0.9771649,0.0001731771,0.009492894,0.000008697412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9423203,0.01083867,0.03438789,0.0005904337,0.0001762676,0.00007831838,0.0009936533,0.0008144472,0.009800117],"genre_scores_gemma":[0.9825231,0.001716793,0.005945832,0.0001408507,0.00005276906,0.00003370909,0.001037504,0.00006786048,0.00848163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003726719,"threshold_uncertainty_score":0.01246715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693205980421906,"score_gpt":0.2883709051255457,"score_spread":0.2714388453213266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}