{"id":"W4291222812","doi":"10.1016/j.ymthe.2022.08.005","title":"DDX5 mRNA-targeting antisense oligonucleotide as a new promising therapeutic in combating castration-resistant prostate cancer","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Institut National de la Santé et de la Recherche Médicale; Centre de Recherche en Cancérologie de Marseille; Infrastructures en Biologie Santé et Agronomie","keywords":"Prostate cancer; Cancer research; Biology; Downregulation and upregulation; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006685363,0.0002454599,0.0002177529,0.0001244104,0.00032397,0.00008796657,0.0003140265,0.00007781825,0.000186973],"category_scores_gemma":[0.000104087,0.0002580779,0.0001064067,0.0003748533,0.00005061822,0.00000857164,0.0001806838,0.0003614254,0.000007065574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001233907,"about_ca_system_score_gemma":0.0008187568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539617,"about_ca_topic_score_gemma":0.0001121061,"domain_scores_codex":[0.9974697,0.0004763312,0.000419385,0.0005746519,0.0004678052,0.0005920874],"domain_scores_gemma":[0.9992185,0.00001611662,0.0001202029,0.000401557,0.0000743206,0.0001692989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004864535,0.0000956618,0.001457624,0.00001436806,0.00007157291,0.000162159,0.0005355225,0.002836359,0.9759385,0.00005036749,0.0001592953,0.01819209],"study_design_scores_gemma":[0.00206395,0.0006631481,0.0008260865,0.00002962556,0.000005803642,0.00003155307,0.0003682575,0.0005211843,0.970437,0.0002753001,0.02440307,0.0003749566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897102,0.006949455,0.0002647369,0.001527812,0.00007712276,0.001104623,0.00001547263,0.00002685593,0.0003237172],"genre_scores_gemma":[0.9962758,0.0004062748,0.0008800135,0.00131754,0.00008562837,0.0002848256,0.00007009519,0.00008598704,0.0005938544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02424377,"threshold_uncertainty_score":0.9999871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844297205401304,"score_gpt":0.3096450894375739,"score_spread":0.2912021173835609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}