{"id":"W4291227607","doi":"10.1016/j.jaci.2022.07.026","title":"Combined IFN-γ and JAK inhibition to treat hemophagocytic lymphohistiocytosis in mice","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Ruxolitinib; Medicine; Hemophagocytic lymphohistiocytosis; Immunology; Janus kinase; Hematopoietic stem cell transplantation; Transplantation; Cytokine; Disease; Internal medicine; Bone marrow; Myelofibrosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007833047,0.00009553609,0.0005158287,0.0002497468,0.0001138303,0.000009319731,0.00007694236,0.0001079907,0.0002652225],"category_scores_gemma":[0.0003360142,0.0000837938,0.00009639819,0.0001778672,0.0001702253,0.00007314674,0.0001804838,0.0005994854,0.000006449271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001065891,"about_ca_system_score_gemma":0.0002114603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004518566,"about_ca_topic_score_gemma":0.00001768287,"domain_scores_codex":[0.9983679,0.0002731637,0.0008468042,0.0001534965,0.0001678714,0.0001907314],"domain_scores_gemma":[0.9992461,0.000254622,0.0001979183,0.000107251,0.00008780073,0.0001063139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1175852,0.01211922,0.2238428,0.0003180341,0.005608528,0.007889521,0.005538381,0.000277997,0.1217465,0.005337402,0.01694234,0.482794],"study_design_scores_gemma":[0.02846316,0.01727015,0.9165607,0.000152518,0.0001307884,0.002071408,0.003430214,0.0002486989,0.001125787,0.0009027918,0.02937451,0.0002692412],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911094,0.003446652,0.0000136198,0.004693055,0.0001502438,0.0001171032,0.000001389344,0.000005421142,0.0004631172],"genre_scores_gemma":[0.9939061,0.004380779,0.00008288401,0.001032427,0.00004073786,0.000007600569,0.000003712926,0.0000102272,0.000535516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6927179,"threshold_uncertainty_score":0.3417012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02465513539906328,"score_gpt":0.3281598876743544,"score_spread":0.3035047522752912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}