{"id":"W4291227654","doi":"10.1038/s41375-022-01658-2","title":"Molecular determinants of outcomes in relapsed or refractory mantle cell lymphoma treated with ibrutinib or temsirolimus in the MCL3001 (RAY) trial","year":2022,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"Ibrutinib; Mantle cell lymphoma; Temsirolimus; Oncology; Internal medicine; Blastoid; International Prognostic Index; Cohort; Medicine; CDKN2A; Hematology; Gene expression profiling; Lymphoma; Clinical trial; Splenic marginal zone lymphoma; Cancer research; Biology; Bioinformatics; Diffuse large B-cell lymphoma; Leukemia; Gene; Gene expression; Genetics; Cancer; Chronic lymphocytic leukemia; Discovery and development of mTOR inhibitors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009231271,0.0003129054,0.0008415624,0.0004216822,0.00009166869,0.00001761242,0.0005631612,0.0001626399,0.0003603974],"category_scores_gemma":[0.0003565194,0.0001737904,0.0001308237,0.001178441,0.000173337,0.00005834875,0.0002004917,0.000503306,0.00001741373],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.01544374,"about_ca_system_score_gemma":0.01268491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004547677,"about_ca_topic_score_gemma":0.00080254,"domain_scores_codex":[0.9963282,0.0005101657,0.0007872117,0.000520482,0.001165791,0.0006881349],"domain_scores_gemma":[0.9978151,0.0007763437,0.0002400341,0.0009960443,0.00005193364,0.0001204933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.752797,0.008488979,0.1010535,0.0014629,0.0003310678,0.09661284,0.008726988,0.001896607,0.01164658,0.00005121078,0.002058794,0.01487352],"study_design_scores_gemma":[0.9113816,0.01238232,0.03751943,0.0003157532,0.0002188087,0.001254243,0.003996019,0.0123157,0.01604451,0.00002126002,0.003888183,0.0006621883],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957826,0.0001194207,0.000001495683,0.0001023514,0.00008957983,0.001839342,0.00002379378,0.00003641049,0.002005037],"genre_scores_gemma":[0.9951498,0.00002774225,0.00009471944,0.0004094388,0.00004607824,0.0003868459,0.00002383238,0.00006891212,0.003792634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1585845,"threshold_uncertainty_score":0.9929122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02818891244314025,"score_gpt":0.3080516541544759,"score_spread":0.2798627417113356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}