{"id":"W4291227790","doi":"10.1093/brain/awac299","title":"Tau positron emission tomography in preclinical Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Canadian Institutes of Health Research; GHR Foundation; Northern California Institute for Research and Education; Foundation for Neurologic Diseases; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Brigham and Women's Hospital; Medpace; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Temporal cortex; Pittsburgh compound B; Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; Fusiform gyrus; Amyloid (mycology); Neuroimaging; Neurodegeneration; Positron emission tomography; Psychology; Superior temporal gyrus; Neuroscience; Temporal lobe; Middle temporal gyrus; Cortex (anatomy); Medicine; Internal medicine; Disease; Pathology; Cognition; Functional magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005896657,0.00007986378,0.0001319402,0.0001937241,0.00009274401,0.00001113325,0.00009129343,0.00002072272,0.001962264],"category_scores_gemma":[0.0001529831,0.00007321119,0.0001097845,0.0003489888,0.00004068664,0.00003904582,0.0001696152,0.0002896295,0.00002212634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003577863,"about_ca_system_score_gemma":0.0001380843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002367425,"about_ca_topic_score_gemma":0.000002493905,"domain_scores_codex":[0.9985983,0.0002276184,0.0001834624,0.0002566756,0.000470394,0.0002635331],"domain_scores_gemma":[0.9993942,0.0001174922,0.00002578312,0.0001755372,0.00002393295,0.0002630131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001200542,0.001125178,0.935831,0.00002248872,0.0000497757,0.0003904559,0.0001017424,0.000001376249,0.00290717,0.00009928236,0.02820618,0.03006486],"study_design_scores_gemma":[0.002190564,0.0006574249,0.9617316,0.00003480868,0.00006177619,0.000010035,0.0001417428,0.000178879,0.0005518214,0.000445284,0.03390488,0.00009116149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796637,0.00107521,0.00002578932,0.01391284,0.00007968007,0.000650038,0.00001847593,0.00004237402,0.004531837],"genre_scores_gemma":[0.9952153,0.00001059682,0.00007185571,0.002284631,0.00005982798,0.0001612158,0.00009762158,0.00001290608,0.002086073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0299737,"threshold_uncertainty_score":0.9989501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0404551226178498,"score_gpt":0.37879667644954,"score_spread":0.3383415538316902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}