{"id":"W4291227790","doi":"10.1093/brain/awac299","title":"Tau positron emission tomography in preclinical Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Canadian Institutes of Health Research; GHR Foundation; Northern California Institute for Research and Education; Foundation for Neurologic Diseases; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Brigham and Women's Hospital; Medpace; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Temporal cortex; Pittsburgh compound B; Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; Fusiform gyrus; Amyloid (mycology); Neuroimaging; Neurodegeneration; Positron emission tomography; Psychology; Superior temporal gyrus; Neuroscience; Temporal lobe; Middle temporal gyrus; Cortex (anatomy); Medicine; Internal medicine; Disease; Pathology; Cognition; Functional magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001616728,0.0003779154,0.0004058944,0.0006777915,0.0002160448,0.0004037347,0.0002867505,0.0004296266,0.0008756162],"category_scores_gemma":[0.001397592,0.0002115555,0.0002385472,0.0005121664,0.0003219637,0.0003606447,0.0002569148,0.0004668779,0.0002480789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004257036,"about_ca_system_score_gemma":0.0003874084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002278335,"about_ca_topic_score_gemma":0.004034318,"domain_scores_codex":[0.9997659,0.0001409158,0.00001430026,0.00002647249,0.00002731693,0.00002507101],"domain_scores_gemma":[0.9997699,0.00008478658,0.0000515672,0.00002278607,0.00004137144,0.0000295577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009244648,0.001032494,0.7388243,0.0007960231,0.0005147836,0.00351099,0.000344785,0.002904712,0.02695654,0.002642869,0.008006503,0.2052214],"study_design_scores_gemma":[0.0009179155,0.004682642,0.94213,0.0003518352,0.0004771521,0.009557181,0.0003009071,0.005657061,0.007718531,0.006662418,0.02148296,0.00006134357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9286935,0.05159581,0.004430521,0.00175275,0.0001103459,0.0002087337,0.0006833436,0.00005480665,0.01247014],"genre_scores_gemma":[0.9850968,0.009766487,0.002606192,0.000349494,0.00006571501,0.0001057606,0.0004032511,0.000005583118,0.001600771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002278335,"threshold_uncertainty_score":0.008550167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0404551226178498,"score_gpt":0.37879667644954,"score_spread":0.3383415538316902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}