{"id":"W4291301625","doi":"10.1101/2022.08.11.503708","title":"Polynuclear ruthenium complexes are effective antibiotics against <i>Pseudomonas aeruginosa</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Health Canada; McMaster University","funders":"Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; National Science Foundation","keywords":"Antibiotics; Pseudomonas aeruginosa; Antimicrobial; Ruthenium; Antibacterial activity; Microbiology; Bacteria; Biology; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135636,0.000220099,0.0001679779,0.0001395171,0.00009909318,0.0002273848,0.0001343734,0.0002432421,0.002083563],"category_scores_gemma":[0.0001376587,0.0001069085,0.00009252068,0.00009646103,0.0001898508,0.0001130928,0.0001170705,0.0002955356,0.0005944723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717593,"about_ca_system_score_gemma":0.00008707574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005136587,"about_ca_topic_score_gemma":0.000575067,"domain_scores_codex":[0.9999003,0.00001664169,0.000004229926,0.00002021171,0.00004141169,0.00001731489],"domain_scores_gemma":[0.9999573,0.00001062225,0.00001449834,0.000003944311,0.000006456993,0.00000712837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007131086,0.00000892973,0.0001196872,0.00003527757,0.000003149661,0.00002964834,0.000005796473,0.0001259734,0.9979584,0.0002012594,0.0002144689,0.001226129],"study_design_scores_gemma":[0.00001506823,0.00007427335,0.001174574,0.000003695423,0.000007414755,0.000163234,0.00001315675,0.001012958,0.9942069,0.0001244684,0.003200966,0.000003223445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789974,0.003624332,0.008665184,0.0007061241,0.00005944843,0.000025754,0.0005016356,0.0004077409,0.007012319],"genre_scores_gemma":[0.9913409,0.0005664756,0.003279019,0.00007592266,0.000009681062,0.000006004382,0.0003855735,0.00004875398,0.004287701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002083563,"threshold_uncertainty_score":0.006970227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007887529931694818,"score_gpt":0.2175648745190377,"score_spread":0.2096773445873429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}