{"id":"W4291383263","doi":"10.1186/s13395-022-00303-x","title":"Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells","year":2022,"lang":"en","type":"article","venue":"Skeletal Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Harvard University; Fondation pour la Recherche Médicale; Faculty of Arts and Sciences; National Institutes of Health; Glenn Foundation for Medical Research; Burroughs Wellcome Fund","keywords":"Myogenesis; Progenitor cell; Biology; Chromatin; Cell biology; MyoD; Transcription factor; Skeletal muscle; Stem cell; Cell cycle; Progenitor; Myocyte; Cell; Genetics; Gene; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129833,0.0002867125,0.0001911269,0.0001417686,0.0001625416,0.0002897481,0.0002121184,0.0002060764,0.001213324],"category_scores_gemma":[0.0001016546,0.0001499197,0.0002555957,0.0001080736,0.0002570145,0.0001582087,0.0002635324,0.0004254681,0.0002971355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002968037,"about_ca_system_score_gemma":0.0002235031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005830142,"about_ca_topic_score_gemma":0.001175037,"domain_scores_codex":[0.9998839,0.000007571528,0.00001093657,0.00004263311,0.00003357589,0.00002127365],"domain_scores_gemma":[0.999896,0.00001948109,0.00003566905,0.0000130314,0.00001055513,0.00002521141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001821707,0.00000525512,0.0001085505,0.00001560414,0.000001691799,0.00001191131,0.000006243174,0.00002730917,0.9994036,0.0000237094,0.000007201024,0.000370709],"study_design_scores_gemma":[0.000007636488,0.000141755,0.00641987,0.000005867715,0.00001233023,0.0001136629,0.00002770308,0.0007401292,0.9908431,0.00003256378,0.001651995,0.000003476519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924482,0.0008718867,0.005201078,0.00006049958,0.00002592137,0.00002226734,0.0004692732,0.00007921968,0.000821705],"genre_scores_gemma":[0.9926853,0.0005936495,0.003578704,0.00006414112,0.000008885003,0.00005743983,0.0007948122,0.00003919231,0.002177936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213324,"threshold_uncertainty_score":0.004058957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005012366424955221,"score_gpt":0.2324987105875669,"score_spread":0.2274863441626116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}