{"id":"W4291397446","doi":"10.1016/j.cbi.2022.110087","title":"Harmaline downregulates angiogenesis markers and suppresses the growth of 4T1 breast cancer cells in vivo and in vitro","year":2022,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Mazandaran University of Medical Sciences","keywords":"Harmaline; Angiogenesis; In vivo; Pharmacology; Doxorubicin; Medicine; In vitro; Endocrinology; Chemistry; Internal medicine; Biology; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393644,0.0001114078,0.0001556585,0.00004534823,0.00007158266,0.00001134472,0.0001203715,0.00005909766,0.0002364078],"category_scores_gemma":[0.00003409113,0.0000782017,0.00005791152,0.0001000681,0.0001787976,0.000006585876,0.0002241725,0.0001147457,1.487592e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001984804,"about_ca_system_score_gemma":0.00001367765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000350512,"about_ca_topic_score_gemma":0.00007483812,"domain_scores_codex":[0.9992942,0.00007919621,0.0001701475,0.0002594118,0.00004975466,0.0001473196],"domain_scores_gemma":[0.9996492,0.0001159085,0.00006847112,0.0001092513,0.00002457038,0.00003259048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004319535,0.0001238863,0.01966636,0.000009122965,0.00003116138,0.000001278564,0.00003064969,0.000009540858,0.9782327,0.00000230077,0.000596804,0.0008642366],"study_design_scores_gemma":[0.0002126525,0.00004009061,0.04699939,0.000008012588,0.00001092359,0.00004131898,0.0003703984,0.0000573365,0.9505134,0.00002011167,0.001625844,0.0001005751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974898,0.0007736473,0.000002689663,0.001153374,0.00006033691,0.0001055458,0.0003059362,0.00000411256,0.0001045572],"genre_scores_gemma":[0.9987335,0.000816252,0.00006924215,0.0001642516,0.00004332357,0.00007290835,0.00002740262,0.000006276407,0.00006687595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02771937,"threshold_uncertainty_score":0.3188973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148966575396572,"score_gpt":0.2437663283889446,"score_spread":0.2322766626349789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}