{"id":"W4291582556","doi":"10.1016/j.str.2022.07.007","title":"Integrative model of the FSH receptor reveals the structural role of the flexible hinge region","year":2022,"lang":"en","type":"article","venue":"Structure","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute","keywords":"Receptor; G protein-coupled receptor; Follicle-stimulating hormone receptor; Signal transduction; Cell biology; Biology; Subfamily; Hormone receptor; Transmembrane domain; Biophysics; Biochemistry; Hormone; Chemistry; Follicle-stimulating hormone; Genetics; Luteinizing hormone; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100472,0.0006046748,0.0004625227,0.0002298082,0.0005943542,0.0005613508,0.001253364,0.0005847901,0.00549995],"category_scores_gemma":[0.00009471797,0.000259395,0.0005514201,0.000157402,0.0005872427,0.0009106212,0.0003593908,0.000684624,0.0008923328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000386079,"about_ca_system_score_gemma":0.000462108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001601362,"about_ca_topic_score_gemma":0.0009436196,"domain_scores_codex":[0.9999578,0.000006006083,0.000001645973,0.0000143643,0.00001007016,0.00001020043],"domain_scores_gemma":[0.9999682,0.000005966843,0.000007139701,0.000004416515,0.000003877311,0.00001041151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007834251,0.0001541035,0.001691063,0.0003987372,0.0001224718,0.001581384,0.0003605123,0.1242007,0.6128822,0.2359205,0.002358813,0.01954609],"study_design_scores_gemma":[0.0001959216,0.0007161747,0.00636032,0.00005444866,0.0001456438,0.0009729174,0.0005161779,0.8056068,0.05429207,0.1126335,0.01838412,0.0001219978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.678422,0.003554471,0.2855521,0.001721963,0.0002953559,0.00006191857,0.0007810369,0.001187761,0.02842351],"genre_scores_gemma":[0.9803107,0.001104667,0.01462526,0.0001094538,0.0000421277,0.00004682385,0.0003433571,0.0000482973,0.00336936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00549995,"threshold_uncertainty_score":0.01839918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190120385087013,"score_gpt":0.235748955809537,"score_spread":0.2238477519586669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}