{"id":"W4291605651","doi":"10.1097/tp.0000000000004285","title":"Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Renal Allograft Rejection: Accumulation of Antibody-neutralized Interleukin-6 Without Signs of Proinflammatory Rebound Phenomena","year":2022,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"","keywords":"Proinflammatory cytokine; Medicine; Antibody; Immunology; Interleukin; Cytokine; Placebo; Interleukin 6; Neutralization; Kidney; Internal medicine; Pharmacology; Gastroenterology; Inflammation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001332868,0.0004044636,0.0008099377,0.0002675167,0.0001745277,0.0002848426,0.0002836231,0.0004602758,0.000922156],"category_scores_gemma":[0.000677902,0.0002013637,0.0002841075,0.0001380158,0.0004317568,0.0003319448,0.0001242128,0.0008989422,0.0002045186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003181618,"about_ca_system_score_gemma":0.0004168136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002606112,"about_ca_topic_score_gemma":0.000581699,"domain_scores_codex":[0.9997205,0.0001158969,0.00002796173,0.00003741972,0.00004448993,0.00005365666],"domain_scores_gemma":[0.999553,0.0001051729,0.0001195869,0.00003460977,0.00003458819,0.0001529777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2447263,0.01470931,0.0133523,0.0005444386,0.0003293422,0.0003376934,0.00009284457,0.0009620274,0.6421547,0.0001170044,0.0004597393,0.08221427],"study_design_scores_gemma":[0.0763922,0.609857,0.08948325,0.00008015806,0.000879114,0.001691588,0.00005904023,0.003562507,0.2152778,0.0001511603,0.002527033,0.00003904849],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981546,0.001234471,0.0003020925,0.0000499017,0.00002186557,0.00005701236,0.00002290764,0.00001092323,0.0001462502],"genre_scores_gemma":[0.9988301,0.0004010203,0.0003830782,0.00005584918,0.00004395248,0.00004342116,0.00005854205,0.000002511242,0.000181484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001332868,"threshold_uncertainty_score":0.007048965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0380998898436672,"score_gpt":0.3607683759637246,"score_spread":0.3226684861200574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}