{"id":"W4291605651","doi":"10.1097/tp.0000000000004285","title":"Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Renal Allograft Rejection: Accumulation of Antibody-neutralized Interleukin-6 Without Signs of Proinflammatory Rebound Phenomena","year":2022,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"","keywords":"Proinflammatory cytokine; Medicine; Antibody; Immunology; Interleukin; Cytokine; Placebo; Interleukin 6; Neutralization; Kidney; Internal medicine; Pharmacology; Gastroenterology; Inflammation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004888777,0.0003819777,0.0009342947,0.0008606068,0.0001431255,0.00002362851,0.0001898176,0.0001339376,0.0002905281],"category_scores_gemma":[0.00001739097,0.0003689215,0.0002817597,0.0008564782,0.0001475418,0.0003504637,0.00002018194,0.00039543,0.000006737432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002255548,"about_ca_system_score_gemma":0.000226815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000480223,"about_ca_topic_score_gemma":0.0001049145,"domain_scores_codex":[0.996547,0.0003238768,0.001410245,0.0005435441,0.0007830331,0.0003922309],"domain_scores_gemma":[0.9984937,0.0001958921,0.0006573577,0.0003590172,0.0001765232,0.0001175215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005294926,0.0006974121,0.3418099,0.001460009,0.0003421983,0.0002575432,0.003260055,0.001426338,0.6448852,0.0003522201,0.000004175493,0.0002100404],"study_design_scores_gemma":[0.02610153,0.002668392,0.8539377,0.001908977,0.0009642372,0.0006621853,0.0007948405,0.002681094,0.1093082,0.0001221219,0.0002410674,0.0006095877],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929088,0.0001488507,0.003898177,0.00009246306,0.0002700855,0.001412729,0.0003211681,0.00009975899,0.0008480129],"genre_scores_gemma":[0.9914269,0.000619628,0.0007987345,0.00005926792,0.00005328338,0.00006517679,0.006767237,0.00005960556,0.0001501574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.535577,"threshold_uncertainty_score":0.9998763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0380998898436672,"score_gpt":0.3607683759637246,"score_spread":0.3226684861200574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}