{"id":"W4291666838","doi":"10.21203/rs.3.rs-1950536/v1","title":"Automechanical gating of Piezo1 triggers the fusogenic steps in macropinocytosis","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Garron Family Cancer Centre; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"PIEZO1; Gating; Pinocytosis; Chemistry; Biophysics; Biology; Cell; Ion channel; Endocytosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002183622,0.0002458683,0.0002520579,0.0001665287,0.0002867275,0.0006383449,0.0002386514,0.0006209725,0.003679813],"category_scores_gemma":[0.0005227437,0.0001640424,0.0002008245,0.0001692125,0.0003650792,0.0008456091,0.0004835763,0.0007184686,0.0007515537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003695026,"about_ca_system_score_gemma":0.0002332143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002516413,"about_ca_topic_score_gemma":0.0003345914,"domain_scores_codex":[0.9998173,0.00001287436,0.000008508931,0.00004297659,0.00006273438,0.00005569376],"domain_scores_gemma":[0.9998925,0.00003180603,0.00002464403,0.00001689138,0.00001102466,0.00002315807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004036262,0.00004856398,0.000889273,0.00007175074,0.000008365554,0.000217306,0.00005468877,0.0004866635,0.9824155,0.004698351,0.000685583,0.01002054],"study_design_scores_gemma":[0.0000716182,0.0002034402,0.02328652,0.00002572702,0.00001071656,0.0005182318,0.0001495488,0.01359357,0.9493176,0.00678412,0.006010133,0.00002875747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774637,0.001917296,0.01193006,0.00117104,0.0002942303,0.00003122517,0.0005772953,0.0003112796,0.006303845],"genre_scores_gemma":[0.995758,0.0004952875,0.00133049,0.0001280558,0.00004585715,0.00001803022,0.0002178266,0.0000305289,0.001975932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003679813,"threshold_uncertainty_score":0.01231021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1224257397275407,"score_gpt":0.4359518592905482,"score_spread":0.3135261195630075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}