{"id":"W4291777605","doi":"10.1093/gerona/glac168","title":"Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis","year":2022,"lang":"en","type":"article","venue":"The Journals of Gerontology Series A","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute on Aging; National Institutes of Health","keywords":"dNaM; Calorie restriction; Epigenome; CpG site; DNA methylation; Internal medicine; Medicine; Physiology; Waist; Endocrinology; Biology; Body mass index; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003058069,0.0003794292,0.001030994,0.0004122095,0.0003467924,0.0007453617,0.0004138507,0.0005638468,0.002319275],"category_scores_gemma":[0.005278606,0.000186287,0.00101784,0.001147701,0.0002113664,0.0003518801,0.0004484463,0.0009036215,0.0001434093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001991218,"about_ca_system_score_gemma":0.0003682591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001857288,"about_ca_topic_score_gemma":0.002633145,"domain_scores_codex":[0.9977263,0.001192942,0.0001682197,0.0006582424,0.0001615657,0.00009284144],"domain_scores_gemma":[0.998647,0.0004846097,0.0003732893,0.0002572931,0.0001261727,0.000111508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1121173,0.0004312876,0.7395595,0.005296807,0.06476778,0.0005077224,0.0001796419,0.001946208,0.008598796,0.002170625,0.01780532,0.04661885],"study_design_scores_gemma":[0.008625766,0.002857147,0.9507946,0.0003021313,0.02264487,0.0003609817,0.00005941023,0.00208614,0.00116886,0.001487429,0.009577592,0.00003502183],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9379123,0.03276633,0.005529266,0.00115045,0.0003631395,0.0006775229,0.01529908,0.0001080867,0.006193866],"genre_scores_gemma":[0.9838113,0.002128867,0.003550176,0.0007268967,0.0001641563,0.001065567,0.006858821,0.00003469942,0.001659401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003058069,"threshold_uncertainty_score":0.01617283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03430851167692296,"score_gpt":0.3219494529445336,"score_spread":0.2876409412676106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}