{"id":"W4291885997","doi":"10.3390/jof8080846","title":"Cryptococcus neoformans Prp8 Intein: An In Vivo Target-Based Drug Screening System in Saccharomyces cerevisiae to Identify Protein Splicing Inhibitors and Explore Its Dynamics","year":2022,"lang":"en","type":"article","venue":"Journal of Fungi","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Dalhousie University; University of Ottawa","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Intein; Protein splicing; RNA splicing; URA3; Biology; Cryptococcus neoformans; Saccharomyces cerevisiae; Genetics; Gene; Antifungal drug; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001125708,0.0001789866,0.0005184421,0.0008644851,0.0001786621,0.00005163536,0.0001090434,0.00004117126,0.00004935822],"category_scores_gemma":[0.00007964933,0.0001555543,0.0000989118,0.0006155928,0.00001750328,0.0003200748,0.0001167734,0.0006271657,0.000001317664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005362716,"about_ca_system_score_gemma":0.00009160369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001586341,"about_ca_topic_score_gemma":0.0002320003,"domain_scores_codex":[0.998233,0.0001311044,0.0007719022,0.0001892998,0.0003914054,0.0002833155],"domain_scores_gemma":[0.9992052,0.00005943168,0.0002979426,0.0001303942,0.0001410158,0.0001659697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"qualitative","study_design_scores_codex":[0.003621396,0.001591763,0.6630242,0.004298341,0.00043433,0.003077933,0.02627536,0.03566236,0.2324395,0.001173949,0.002782197,0.02561864],"study_design_scores_gemma":[0.02195193,0.01527877,0.2423485,0.03145039,0.0005525726,0.002821589,0.3311966,0.237443,0.1019031,0.0001538581,0.01239566,0.002504062],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996024,0.001399479,0.0005874365,0.0007550414,0.0002608981,0.0007999013,0.00001288403,0.00002179314,0.0001386071],"genre_scores_gemma":[0.9977405,0.00001995759,0.001781594,0.0001039945,0.000178561,0.00008516452,0.000002831136,0.00002512596,0.00006226607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4206757,"threshold_uncertainty_score":0.6343319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224898062823617,"score_gpt":0.29287289855771,"score_spread":0.2706239179294738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}