{"id":"W4291885997","doi":"10.3390/jof8080846","title":"Cryptococcus neoformans Prp8 Intein: An In Vivo Target-Based Drug Screening System in Saccharomyces cerevisiae to Identify Protein Splicing Inhibitors and Explore Its Dynamics","year":2022,"lang":"en","type":"article","venue":"Journal of Fungi","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Dalhousie University; University of Ottawa","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Intein; Protein splicing; RNA splicing; URA3; Biology; Cryptococcus neoformans; Saccharomyces cerevisiae; Genetics; Gene; Antifungal drug; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184394,0.0004701615,0.0003417163,0.000263398,0.0001591377,0.0002573132,0.0003447346,0.0003163235,0.000715898],"category_scores_gemma":[0.0001013704,0.000182694,0.0002302188,0.0002662161,0.0001461314,0.0001544591,0.0002532454,0.0005093827,0.0003509021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003387523,"about_ca_system_score_gemma":0.0002065457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002136171,"about_ca_topic_score_gemma":0.002047123,"domain_scores_codex":[0.9997786,0.0000407429,0.00002906581,0.0000579459,0.00007202061,0.00002163222],"domain_scores_gemma":[0.9999105,0.00001477049,0.00002611551,0.00001883174,0.00001267251,0.00001720563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004610392,0.00003312899,0.0001169638,0.00002077002,0.000002928999,0.00002811077,0.000007019774,0.0001162257,0.9988714,0.000055493,0.00002992681,0.000671817],"study_design_scores_gemma":[0.000009214416,0.0001343957,0.0009214905,0.000002416817,0.000009201359,0.0001008373,0.000007913149,0.001905043,0.9958988,0.00001732934,0.0009879892,0.000005322079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964689,0.0006898914,0.02940809,0.0001567699,0.00005638777,0.0001976297,0.002394882,0.0006772655,0.001730204],"genre_scores_gemma":[0.9538429,0.0007083138,0.03887027,0.00008299198,0.000006281538,0.0001325862,0.002563383,0.0001273241,0.003665959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002136171,"threshold_uncertainty_score":0.004247487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224898062823617,"score_gpt":0.29287289855771,"score_spread":0.2706239179294738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}