{"id":"W4291964188","doi":"10.1128/spectrum.02432-21","title":"UPEC Colonic-Virulence and Urovirulence Are Blunted by Proanthocyanidins-Rich Cranberry Extract Microbial Metabolites in a Gut Model and a 3D Tissue-Engineered Urothelium","year":2022,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Urinary Tract Infections Management","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Urothelium; Microbiology; Virulence; CRANBERRY JUICE; Escherichia coli; Biology; Akkermansia muciniphila; Gut flora; Proanthocyanidin; Feces; Urinary system; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382077,0.0003363028,0.0002626434,0.0002089861,0.0001264285,0.0003241678,0.0001256025,0.0003235595,0.0008293106],"category_scores_gemma":[0.00009047077,0.0001342027,0.0003224715,0.0001190576,0.0002296468,0.0002992558,0.0002857282,0.0007945911,0.0001166541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538278,"about_ca_system_score_gemma":0.000189254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005470534,"about_ca_topic_score_gemma":0.001042541,"domain_scores_codex":[0.9998358,0.00002917256,0.00001170099,0.00002799655,0.00004918775,0.00004600272],"domain_scores_gemma":[0.999892,0.00001057627,0.0000333,0.00001113389,0.00000981577,0.00004330661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002648884,0.0001207974,0.0001508011,0.00004334912,0.000004864457,0.00005102156,0.00002328593,0.0001011016,0.9982738,0.0000360751,0.00002027758,0.0009096435],"study_design_scores_gemma":[0.0000290702,0.001991122,0.006161737,0.00001428056,0.00002380072,0.0001450649,0.00008638651,0.001214761,0.9890106,0.00003789101,0.001277474,0.000007717769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978023,0.0006390174,0.001012815,0.00005922232,0.00002167322,0.0000146395,0.00009190798,0.00002488838,0.0003335937],"genre_scores_gemma":[0.9962448,0.0004973258,0.001849076,0.00004206891,0.000004946391,0.00002489664,0.0001607648,0.000009260617,0.001166789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008293106,"threshold_uncertainty_score":0.002774298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008305518330442678,"score_gpt":0.2325066587661809,"score_spread":0.2242011404357382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}