{"id":"W4291964213","doi":"10.3389/fnume.2022.963698","title":"Historical efforts to develop 99mTc-based amyloid plaque targeting radiotracers","year":2022,"lang":"en","type":"review","venue":"Frontiers in Nuclear Medicine","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; Lawson Health Research Institute; Western University","funders":"","keywords":"Positron emission tomography; Medicine; Single-photon emission computed tomography; Gold standard (test); Nuclear medicine; Spect imaging; Medical physics; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003048556,0.0009192229,0.0008364688,0.001822947,0.0005329009,0.002129813,0.0009547026,0.001781431,0.002443206],"category_scores_gemma":[0.002532397,0.0006879751,0.0005309193,0.001748432,0.002336439,0.002676815,0.001260581,0.002886456,0.002090973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002358438,"about_ca_system_score_gemma":0.001354977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00138446,"about_ca_topic_score_gemma":0.001312537,"domain_scores_codex":[0.9991407,0.0002361681,0.00008660127,0.0002170149,0.0002492624,0.00007018042],"domain_scores_gemma":[0.9987651,0.0005290712,0.0001402758,0.00008446341,0.0004052553,0.0000758787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006554977,0.0004336391,0.001607572,0.01373948,0.0002026306,0.001194961,0.0007838068,0.004174317,0.07742771,0.1531082,0.02339201,0.7232801],"study_design_scores_gemma":[0.00002660367,0.0005314898,0.0006704521,0.001060347,0.00009048489,0.001307045,0.00009575994,0.0005390281,0.04446414,0.009060181,0.9420865,0.00006786706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008439792,0.9497381,0.01632828,0.004433771,0.001082486,0.00008350412,0.0001381539,0.00008988679,0.01966609],"genre_scores_gemma":[0.03391987,0.9239013,0.02470685,0.004301117,0.0009808906,0.0001652417,0.0002208944,0.00008606492,0.0117178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003048556,"threshold_uncertainty_score":0.01711172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03934997688109698,"score_gpt":0.3247029710952485,"score_spread":0.2853529942141515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}