{"id":"W4292055462","doi":"10.1016/j.celrep.2022.111213","title":"The human blood transcriptome exhibits time-of-day-dependent response to hypoxia: Lessons from the highest city in the world","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"European Research Council; Agir pour les Maladies Chroniques; Abisch-Frenkel-Stiftung; Fondation Université Grenoble Alpes; Université Grenoble Alpes; H2020 European Research Council; Agence Nationale de la Recherche; Achelis Foundation","keywords":"Transcriptome; Hypoxia (environmental); Biology; Effects of high altitude on humans; Altitude (triangle); Circadian rhythm; Immune system; Gene; Computational biology; Gene expression; Genetics; Endocrinology; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008129234,0.00006976737,0.000144387,0.0001190054,0.000135454,0.0002674242,0.00006183572,0.0001358062,0.0008957867],"category_scores_gemma":[0.0001718722,0.00006892831,0.000133353,0.0002299106,0.0001707013,0.0001192472,0.0001859362,0.0001715259,0.0001508492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008384719,"about_ca_system_score_gemma":0.00007619084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001342533,"about_ca_topic_score_gemma":0.003131348,"domain_scores_codex":[0.999948,0.00001110184,0.000001704569,0.00001998304,0.000007528975,0.00001171494],"domain_scores_gemma":[0.9999282,0.00001721055,0.00001931516,0.00001008204,0.00001423077,0.00001092627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005775474,0.0000403579,0.1160775,0.0001604787,0.00009554014,0.0001854393,0.0009997336,0.0002930549,0.8621413,0.0001785139,0.0004823872,0.01876799],"study_design_scores_gemma":[0.000001856879,0.00009376154,0.990482,0.000006261882,0.00001996594,0.0001302268,0.0003201943,0.0002420776,0.00735491,0.0001109504,0.001231767,0.000006046018],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965145,0.0009031246,0.001038703,0.0001735346,0.000009152691,0.00000630943,0.0005881709,0.00001199942,0.0007545857],"genre_scores_gemma":[0.9972162,0.0006575308,0.0005661995,0.00009953148,0.00001421306,0.0000113992,0.0007798854,0.000009196599,0.0006457333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342533,"threshold_uncertainty_score":0.002996743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572094467836866,"score_gpt":0.2585864248453313,"score_spread":0.2428654801669626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}