{"id":"W4292065316","doi":"10.1172/jci159283","title":"HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; Government of Ontario; Terry Fox Research Institute; Canadian Cancer Society; Ontario Institute for Cancer Research","keywords":"Epitope; Immunity; Tumor microenvironment; Inflammation; Cancer research; Immunology; Immune system; Cell biology; Biology; Chemistry; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233426,0.0003557478,0.0001949995,0.0001995186,0.00009151651,0.0002776228,0.0001400517,0.0001167185,0.001491406],"category_scores_gemma":[0.00005539799,0.00009343808,0.0001951586,0.0001091396,0.0001966955,0.00013532,0.0001337502,0.0005023156,0.0003047359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003102775,"about_ca_system_score_gemma":0.0002710781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005006486,"about_ca_topic_score_gemma":0.001399468,"domain_scores_codex":[0.9999195,0.00001212481,0.000005345885,0.00001381778,0.0000202955,0.00002894636],"domain_scores_gemma":[0.9999653,0.000004057041,0.000008920678,0.000003326281,0.000004036055,0.00001427456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002312963,0.00008673546,0.000254199,0.00003997961,0.000006210571,0.00002487547,0.00000767236,0.0001181601,0.9955289,0.0001072312,0.00007128068,0.003523522],"study_design_scores_gemma":[0.00005085305,0.0008846144,0.003632402,0.000004457161,0.00002078502,0.0001158901,0.00002394523,0.001146951,0.9919688,0.0000385188,0.002109477,0.000003245292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909338,0.002792029,0.002936016,0.0001631136,0.00006791855,0.0000668117,0.000236784,0.0001303017,0.00267319],"genre_scores_gemma":[0.9968572,0.0006551838,0.0009502153,0.00003502328,0.00001491631,0.00001698831,0.0001047612,0.000007684098,0.001357883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491406,"threshold_uncertainty_score":0.004989207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0292737729577458,"score_gpt":0.3465560899062941,"score_spread":0.3172823169485482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}