{"id":"W4292079763","doi":"10.1021/acsbiomedchemau.2c00047","title":"Shedding Light on the Elephant in a Dark Room in the Discovery of New Medicine: Highlighting Molecular Pharmaceutics within <i>ACS Bio &amp; Med Chem Au</i>","year":2022,"lang":"en","type":"editorial","venue":"ACS Bio & Med Chem Au","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Pharmacy; Citation; Library science; Medicine; Computer science; Family medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00294462,0.000766996,0.0008739103,0.0002044541,0.0002154524,0.00008202185,0.001714631,0.0009108157,0.00006073687],"category_scores_gemma":[0.00149475,0.0004936978,0.0002721827,0.0006754586,0.0001403684,0.00001599178,0.0005138786,0.001535008,0.000003379899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376365,"about_ca_system_score_gemma":0.001245515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006007192,"about_ca_topic_score_gemma":0.0004722543,"domain_scores_codex":[0.9950371,0.0004451335,0.001156646,0.001044246,0.001471682,0.0008452163],"domain_scores_gemma":[0.9973111,0.0004830561,0.0008235676,0.001123616,0.0001150949,0.0001435692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002152714,0.0001072913,0.00002934035,0.000107531,0.0001687837,0.00003292576,0.002525704,0.00008953504,0.8408487,0.0001370894,0.1555602,0.0001776025],"study_design_scores_gemma":[0.001063159,0.0001834919,0.00000185677,0.000327781,0.0001199209,0.000004521917,0.0008847683,0.0000103892,0.6892688,0.000160908,0.3075706,0.0004037223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8178174,0.004650219,0.0003926007,0.004473291,0.1695126,0.00146195,0.000156243,0.00003867871,0.001497028],"genre_scores_gemma":[0.7991117,0.002249328,0.0002469214,0.001326739,0.1927852,0.0002573987,0.002386261,0.0002616771,0.001374784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1520105,"threshold_uncertainty_score":0.9997514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430348715683732,"score_gpt":0.2796672552029769,"score_spread":0.2653637680461395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}