{"id":"W4292092775","doi":"10.1186/s40478-022-01420-w","title":"Chromosomal instability in adult-type diffuse gliomas","year":2022,"lang":"en","type":"review","venue":"Acta Neuropathologica Communications","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Friedberg Charitable Foundation; Making Headway Foundation; National Institute on Aging; National Institutes of Health; University of Texas Southwestern Medical Center","keywords":"Chromosome instability; Malignancy; Genome instability; Glioma; Cancer; Carcinogenesis; Chromothripsis; Colorectal cancer; Medicine; Disease; Cancer research; Comparative genomic hybridization; Pathology; Biology; Gene; Internal medicine; Genetics; Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003268512,0.0005132286,0.001730221,0.000425552,0.0003571723,0.00003855974,0.001418757,0.0002436648,0.00046096],"category_scores_gemma":[0.001463325,0.000396376,0.00052252,0.001601788,0.0002771799,0.00007147771,0.001851615,0.001408754,0.0001053696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003806409,"about_ca_system_score_gemma":0.0002902448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003421697,"about_ca_topic_score_gemma":0.00003423281,"domain_scores_codex":[0.9960435,0.001641189,0.0009411555,0.0006975065,0.0002903264,0.0003863004],"domain_scores_gemma":[0.9926732,0.001300212,0.0004037306,0.005370899,0.00009156214,0.0001603699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006777202,0.02222884,0.006790028,0.00453446,0.000225904,0.004236697,0.0003938512,3.731189e-7,0.00008656689,0.001494395,0.0007558815,0.9591852],"study_design_scores_gemma":[0.0007631928,0.0004508378,0.004004775,0.001053797,0.0007503195,0.00107765,0.00003174129,0.000008983247,0.000001214498,0.00002000284,0.9915425,0.0002950256],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01221897,0.9795166,9.525706e-8,0.0009603265,0.000163131,0.001992156,0.0001219914,0.0001873213,0.004839438],"genre_scores_gemma":[0.04197584,0.9548162,0.0004124272,0.0002597275,0.00002839449,0.001375802,0.001023909,0.00007346033,0.00003429599],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9907866,"threshold_uncertainty_score":0.9998488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1340067202072409,"score_gpt":0.367791671389337,"score_spread":0.2337849511820961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}