{"id":"W4292111508","doi":"10.1016/j.cmet.2022.07.012","title":"Carbon source availability drives nutrient utilization in CD8+ T cells","year":2022,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":159,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; Paul G. Allen Frontiers Group; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Van Andel Research Institute; Division of Cancer Prevention, National Cancer Institute; Howard Hughes Medical Institute","keywords":"Biology; Citric acid cycle; Cell biology; Effector; CD8; Carbohydrate metabolism; Metabolism; Biochemistry; Immunology; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088555,0.0002562841,0.0002562922,0.0001967431,0.0002251994,0.000887802,0.0003136936,0.0003805107,0.002946251],"category_scores_gemma":[0.0002022949,0.0002644019,0.000219651,0.0001996358,0.0002386414,0.0004902682,0.000376582,0.000738342,0.0005636318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004175577,"about_ca_system_score_gemma":0.0002857276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004978568,"about_ca_topic_score_gemma":0.001787071,"domain_scores_codex":[0.9998161,0.00003249073,0.00001118583,0.0000552402,0.00002779955,0.00005715897],"domain_scores_gemma":[0.9998488,0.00004161603,0.00003043625,0.00001209242,0.00002263522,0.00004444017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006123661,0.00004121066,0.001577105,0.00005842811,0.000006061843,0.0000657111,0.00003063446,0.0001451638,0.9944401,0.000175482,0.00008429807,0.002763482],"study_design_scores_gemma":[0.000130709,0.0006386409,0.04791947,0.00005183611,0.00005873879,0.000305332,0.0006511314,0.007013761,0.939324,0.0007547272,0.003128508,0.00002306623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975557,0.0005506036,0.0005167771,0.0001130372,0.00002798297,0.000006489159,0.0001395481,0.00001904827,0.001070886],"genre_scores_gemma":[0.9976375,0.0002152354,0.0006410171,0.00006585219,0.0000186905,0.00001370546,0.0001411493,0.00001939475,0.00124743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002946251,"threshold_uncertainty_score":0.009856224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01338288904537067,"score_gpt":0.2182750963194934,"score_spread":0.2048922072741228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}