{"id":"W4292133657","doi":"10.1038/s41541-022-00506-9","title":"Working correlates of protection predict SchuS4-derived-vaccine candidates with improved efficacy against an intracellular bacterium, Francisella tularensis","year":2022,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; U.S. Department of Health and Human Services","keywords":"CLPB; Francisella tularensis; Francisella; Tularemia; Biology; Vaccination; Vaccine efficacy; Virology; Microbiology; Intracellular parasite; Immune system; Immunology; Escherichia coli; Genetics; Virulence; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003234608,0.0002888353,0.0003519993,0.0001218182,0.0003204178,0.00005066773,0.0003443703,0.0001479646,0.0001956376],"category_scores_gemma":[0.00008421212,0.0002486642,0.0001000297,0.0003442617,0.00004228614,0.00001455486,0.000242187,0.0003027453,0.00000300332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003317494,"about_ca_system_score_gemma":0.0001177025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001382737,"about_ca_topic_score_gemma":0.0001788785,"domain_scores_codex":[0.9981731,0.0001633779,0.0003850374,0.0005876202,0.0002646233,0.0004262048],"domain_scores_gemma":[0.9988073,0.00002000376,0.0002217093,0.0005701407,0.0002324119,0.0001484703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002354326,0.0002015856,0.02176792,0.00004192324,0.0001185042,0.000007440328,0.0001129969,0.0003554111,0.9581953,0.000003030897,0.000117535,0.01672405],"study_design_scores_gemma":[0.003966988,0.004145154,0.03531449,0.00005761143,0.00007399596,0.00003656197,0.000219829,0.004228023,0.9413962,0.00001577157,0.009980065,0.0005653009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970883,0.0008523214,0.0006885175,0.0000788244,0.0003665987,0.0007374453,0.00004848781,0.00004154901,0.00009793639],"genre_scores_gemma":[0.998286,0.0001916994,0.000297389,0.00003749061,0.0003554422,0.0001396444,0.000445622,0.00006586088,0.000180865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01679907,"threshold_uncertainty_score":0.9999965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009411119477213304,"score_gpt":0.2186689479909978,"score_spread":0.2092578285137845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}