{"id":"W4292136237","doi":"10.1016/j.jaci.2022.08.004","title":"Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; University of Manitoba; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Center for Advancing Translational Sciences; Health Resources and Services Administration; National Institutes of Health; Office of Naval Research; Jazz Pharmaceuticals; Rare Diseases Clinical Research Network; Canadian Institutes of Health Research; Omeros Corporation; Alexion Pharmaceuticals; Invitae; St. Baldrick's Foundation; Eli Lilly and Company","keywords":"Immunodeficiency; Transplantation; Severe combined immunodeficiency; Medicine; Intensive care medicine; Immunology; Biology; Internal medicine; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497877,0.0002192177,0.0002941172,0.0004457467,0.0002917912,0.0003317293,0.0002474369,0.0002911071,0.0009355261],"category_scores_gemma":[0.0004777762,0.0001094172,0.0001785544,0.0002766509,0.0003001218,0.0001880623,0.0003374158,0.0004393623,0.0002185779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001356073,"about_ca_system_score_gemma":0.0001493705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003365541,"about_ca_topic_score_gemma":0.0003247153,"domain_scores_codex":[0.9998862,0.00001990866,0.00001426931,0.0000137474,0.00002067244,0.00004522912],"domain_scores_gemma":[0.9996824,0.00005851366,0.0001046182,0.00004457802,0.00002653245,0.00008330654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005399751,0.0005173043,0.4554963,0.0001332719,0.0001873151,0.04641873,0.0008000329,0.001130558,0.4487725,0.00069462,0.001066406,0.03938313],"study_design_scores_gemma":[0.0001056865,0.003640213,0.7989398,0.00004319564,0.000271652,0.1371076,0.0007537993,0.003356551,0.05182096,0.0006092024,0.003316323,0.00003498447],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992276,0.0001749294,0.00013908,0.00002115708,0.000007602239,0.000004588278,0.00003410836,0.00001106721,0.0003797068],"genre_scores_gemma":[0.9997658,0.00003872062,0.00003214264,0.00001114776,0.000005411711,0.000002386465,0.00004375165,0.000001630528,0.00009905967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009355261,"threshold_uncertainty_score":0.003129661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009231222945209491,"score_gpt":0.2338967852631409,"score_spread":0.2246655623179314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}