{"id":"W4292168416","doi":"10.1101/2022.08.15.504029","title":"Exposure of Greenlandic Inuit and South African VhaVenda men to the persistent DDT metabolite is associated with an altered sperm epigenome at regions implicated in paternal epigenetic transmission and developmental disease – a cross-sectional study","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Health Canada; McGill University Health Centre; Western University; National Research Council Canada; McGill University","funders":"Medical Research Council; Canadian Institutes of Health Research; South African Medical Research Council; McGill University","keywords":"Epigenome; Epigenetics; DNA methylation; Biology; Toxicant; Genetics; H3K4me3; Epigenomics; Histone; Medicine; Internal medicine; Gene; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261287,0.0002489131,0.0002010069,0.0004138722,0.0007651712,0.0004081489,0.0003494011,0.0003807461,0.002471685],"category_scores_gemma":[0.000377079,0.0002659015,0.000316357,0.0005609142,0.0002870896,0.0002572717,0.0003986522,0.0002996201,0.0002052459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004871796,"about_ca_system_score_gemma":0.0003161887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03101468,"about_ca_topic_score_gemma":0.05581551,"domain_scores_codex":[0.9998343,0.00002227394,0.00001438852,0.0000716069,0.00002286933,0.00003451955],"domain_scores_gemma":[0.999844,0.00002121953,0.00005393197,0.00001256034,0.00002676041,0.0000415913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007642547,0.00004692917,0.9967545,0.000031085,0.00007460867,0.0001883132,0.0006970811,0.00001223633,0.0009393272,0.00004380245,0.00009908024,0.001036654],"study_design_scores_gemma":[0.000003665409,0.0001488051,0.9979827,0.00001580404,0.00006185137,0.0003482355,0.0008197153,0.00005476379,0.00009992425,0.00002062469,0.0004407488,0.000003041016],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990351,0.0002855179,0.00005358174,0.00002357647,0.000004499283,0.00001200057,0.0002592703,0.000001260772,0.0003250813],"genre_scores_gemma":[0.9991661,0.0001006617,0.00005349048,0.00002688629,0.000003017067,0.00001169787,0.0001567925,9.474674e-7,0.0004805038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03101468,"threshold_uncertainty_score":0.06166834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944396059173465,"score_gpt":0.2404883889800538,"score_spread":0.2210444283883191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}