{"id":"W4292182380","doi":"10.3390/v14081764","title":"Human Papillomavirus 16 E6 and E7 Oncoproteins Alter the Abundance of Proteins Associated with DNA Damage Response, Immune Signaling and Epidermal Differentiation","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba; Manitoba Health","funders":"","keywords":"Biology; DNA damage; Proteome; Interferon; Keratinocyte; Signal transduction; Cancer research; Cell biology; Immunology; DNA; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006433062,0.0001192427,0.0002694102,0.00008698069,0.000455443,0.00004237565,0.00009531768,0.0000352492,0.0009254133],"category_scores_gemma":[0.0001712095,0.00007861938,0.00003527421,0.0002250804,0.0002150287,0.00009518309,0.000171647,0.0003203602,0.000001052662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001032811,"about_ca_system_score_gemma":0.00008405692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000501866,"about_ca_topic_score_gemma":0.000170843,"domain_scores_codex":[0.998568,0.0002993147,0.0002399333,0.0002156872,0.0004652131,0.0002118418],"domain_scores_gemma":[0.9992567,0.0002301962,0.0001295245,0.0002262988,0.00008749801,0.00006976738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005533326,0.0003708707,0.05098256,0.0001780464,0.0002253257,0.00003471172,0.001391152,0.00001305319,0.9333497,0.0002705371,0.00009883344,0.007551856],"study_design_scores_gemma":[0.002438476,0.001544927,0.8825585,0.00007320892,0.00006758233,0.000008822971,0.000358615,0.00006948249,0.1117669,0.000219916,0.0007720068,0.0001215739],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972502,0.001026877,0.00003536476,0.0005696649,0.00001467023,0.0007261232,0.00006964558,0.00002767675,0.0002797914],"genre_scores_gemma":[0.9990525,0.00002410683,0.0000179768,0.0003443825,0.0000417802,0.0001404278,0.00001941796,0.00002288237,0.0003365375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8315759,"threshold_uncertainty_score":0.9999879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03756080554507472,"score_gpt":0.3154235120573886,"score_spread":0.2778627065123139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}