{"id":"W4292182380","doi":"10.3390/v14081764","title":"Human Papillomavirus 16 E6 and E7 Oncoproteins Alter the Abundance of Proteins Associated with DNA Damage Response, Immune Signaling and Epidermal Differentiation","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba; Manitoba Health","funders":"","keywords":"Biology; DNA damage; Proteome; Interferon; Keratinocyte; Signal transduction; Cancer research; Cell biology; Immunology; DNA; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009303018,0.0002583875,0.0002054421,0.0003271103,0.0001681716,0.0003272637,0.00009458854,0.0002329145,0.0008167482],"category_scores_gemma":[0.0001006697,0.0001100473,0.000282706,0.0002873627,0.0001205514,0.0002521423,0.0002196757,0.0002721847,0.0002491346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000181065,"about_ca_system_score_gemma":0.0001516206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004275426,"about_ca_topic_score_gemma":0.0005038456,"domain_scores_codex":[0.999895,0.00001011011,0.000007141208,0.00002944486,0.00003528911,0.00002306197],"domain_scores_gemma":[0.9999467,0.000008041477,0.00001673072,0.000004926849,0.00001207581,0.00001162706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007269184,0.00001573774,0.0009331565,0.00005378676,0.00001038426,0.00004132423,0.00001333366,0.00001443157,0.9969104,0.00003342095,0.00002629592,0.001875062],"study_design_scores_gemma":[0.000005371682,0.0002360498,0.07828555,0.00001753324,0.00004885875,0.0009602237,0.0001177072,0.0004316622,0.916301,0.000182885,0.003404292,0.000008936959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906529,0.004009474,0.002600939,0.00007632966,0.00003575548,0.00002126454,0.001435293,0.00006165156,0.001106263],"genre_scores_gemma":[0.9821123,0.006372167,0.003882268,0.0001469799,0.00001410007,0.0000386475,0.003035066,0.00002558818,0.004372945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008167482,"threshold_uncertainty_score":0.002732337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03756080554507472,"score_gpt":0.3154235120573886,"score_spread":0.2778627065123139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}