{"id":"W4292200294","doi":"10.3389/fonc.2022.981009","title":"Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biocenter Finland; Syöpäsäätiö; Suomalainen Lääkäriseura Duodecim; Academy of Finland; Norges Forskningsråd; Jane ja Aatos Erkon Säätiö; Biocenter, University of Oulu; European Commission; FP7 People: Marie-Curie Actions; Helse Vest Regionalt Helseføretak; Kerttu Saalasti Säätiö; Finska Läkaresällskapet; Sigrid Juséliuksen Säätiö; Suomen Lääketieteen Säätiö","keywords":"Carcinogenesis; Stromal cell; Downregulation and upregulation; Stroma; Pathology; Cancer research; Myofibroblast; Integrin; Tumor progression; Extracellular matrix; Lysyl oxidase; Tumor microenvironment; Human skin; Wound healing; Biology; Cancer; Cell; Fibrosis; Medicine; Immunology; Immunohistochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007100539,0.0001878231,0.0006105516,0.0006615116,0.00007401218,0.000005698032,0.0005578088,0.0001658314,0.0003810289],"category_scores_gemma":[0.0001822441,0.0001553275,0.0001267425,0.0009652953,0.0002141338,0.00002041381,0.0003105119,0.000893325,0.000005529914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000985173,"about_ca_system_score_gemma":0.0005873065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111589,"about_ca_topic_score_gemma":0.0001849169,"domain_scores_codex":[0.9969075,0.001035313,0.0005434448,0.0004177061,0.0005766232,0.0005193636],"domain_scores_gemma":[0.9988536,0.000308802,0.0001357123,0.0005409418,0.0000715931,0.00008932828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003198186,0.003978318,0.8096116,0.0003657695,0.00004626254,0.009279481,0.01152727,0.0009212515,0.09323189,0.00005599196,0.03533782,0.0324462],"study_design_scores_gemma":[0.01738859,0.02277717,0.6732334,0.00005229193,0.0002609175,0.00419847,0.04877423,0.02350697,0.1626818,0.0006820125,0.04557118,0.0008730161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915417,0.001080225,0.00007156975,0.001155861,0.0003421381,0.001139364,0.00001890928,0.0000162456,0.004633944],"genre_scores_gemma":[0.9966758,0.0000204712,0.001989187,0.0002485569,0.00003770922,0.0001948711,0.00004215748,0.00003487489,0.0007563661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1363782,"threshold_uncertainty_score":0.6334072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509530785770636,"score_gpt":0.2775057911391903,"score_spread":0.262410483281484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}