{"id":"W4292228059","doi":"10.1200/jco.22.00184","title":"Neoadjuvant Chemotherapy, Excision, and Observation for Early Rectal Cancer: The Phase II NEO Trial (CCTG CO.28) Primary End Point Results","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; CancerCare Manitoba; Juravinski Cancer Centre; Queen's University; St. Paul's Hospital; Health Sciences North; University of Manitoba; Ottawa Hospital","funders":"","keywords":"Medicine; Total mesorectal excision; Oxaliplatin; Surgery; Colorectal cancer; Folinic acid; Capecitabine; Chemotherapy; Clinical endpoint; Rectum; Neoadjuvant therapy; Cancer; Fluorouracil; Randomized controlled trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008412179,0.0005962671,0.001013113,0.0001569047,0.0002128336,0.0004902493,0.0002744034,0.0007135828,0.003026339],"category_scores_gemma":[0.001099498,0.0001586917,0.0005868661,0.0001649471,0.0003448765,0.0002719873,0.0001760533,0.001278594,0.0004047098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005791873,"about_ca_system_score_gemma":0.001314993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008873271,"about_ca_topic_score_gemma":0.004681742,"domain_scores_codex":[0.9996468,0.000233018,0.00001200066,0.00003844436,0.00002867255,0.00004099615],"domain_scores_gemma":[0.9995142,0.0001014743,0.0001290644,0.00003660569,0.00004079541,0.0001779668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8836313,0.0122825,0.01020564,0.001536202,0.0008762802,0.0001372469,0.00006983248,0.002307704,0.008593876,0.0005721707,0.01214407,0.06764314],"study_design_scores_gemma":[0.8278291,0.1419735,0.01767103,0.0002544102,0.0007999415,0.000251672,0.00004216668,0.002090378,0.001631873,0.0005043415,0.006927543,0.0000240618],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750749,0.005830097,0.0008294453,0.002109147,0.0004203272,0.003743973,0.002000926,0.00008766258,0.009903473],"genre_scores_gemma":[0.9735916,0.002283867,0.001555899,0.003087048,0.0003453663,0.007491689,0.003090886,0.0000348656,0.008518866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003026339,"threshold_uncertainty_score":0.01012409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1973860804292623,"score_gpt":0.5044359961536334,"score_spread":0.3070499157243711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}