{"id":"W4292228059","doi":"10.1200/jco.22.00184","title":"Neoadjuvant Chemotherapy, Excision, and Observation for Early Rectal Cancer: The Phase II NEO Trial (CCTG CO.28) Primary End Point Results","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; CancerCare Manitoba; Juravinski Cancer Centre; Queen's University; St. Paul's Hospital; Health Sciences North; University of Manitoba; Ottawa Hospital","funders":"","keywords":"Medicine; Total mesorectal excision; Oxaliplatin; Surgery; Colorectal cancer; Folinic acid; Capecitabine; Chemotherapy; Clinical endpoint; Rectum; Neoadjuvant therapy; Cancer; Fluorouracil; Randomized controlled trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005609114,0.0001732427,0.001346349,0.00008267214,0.0002929936,0.00001466872,0.000201293,0.0001978883,0.0003268795],"category_scores_gemma":[0.002783292,0.0001065854,0.0005435258,0.000194209,0.0002011724,0.0001169527,0.0001250856,0.0009929644,0.000001035686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006180786,"about_ca_system_score_gemma":0.001764994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007403741,"about_ca_topic_score_gemma":0.00002651942,"domain_scores_codex":[0.9957973,0.0006131725,0.002373891,0.000307253,0.0006467582,0.0002616163],"domain_scores_gemma":[0.9919525,0.005272239,0.001931597,0.0002211705,0.0003291137,0.000293429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.4819497,0.00282888,0.001936727,0.000009422112,0.000341452,0.0001822725,0.0003624782,0.000007619128,0.0001793347,0.00001655418,0.01210987,0.5000757],"study_design_scores_gemma":[0.3174334,0.1591621,0.09795208,0.00004128126,0.0003829585,0.0003043217,0.0001163165,0.0001508795,0.0000747708,0.0007844914,0.4234793,0.0001181214],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9490285,0.0008058594,0.00005288505,0.04542406,0.002483246,0.001285251,0.00008497458,0.00001292573,0.0008222972],"genre_scores_gemma":[0.9869572,0.001480801,0.001106491,0.006596379,0.002843854,0.0001612927,0.00002842765,0.00003046918,0.0007951123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4999576,"threshold_uncertainty_score":0.4346428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1973860804292623,"score_gpt":0.5044359961536334,"score_spread":0.3070499157243711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}