{"id":"W4292228089","doi":"10.1101/2022.08.17.504304","title":"Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Biology; Progenitor cell; Neural stem cell; Carcinogenesis; Cancer research; Progenitor; Stem cell; Chromatin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003603743,0.0006786962,0.0005380338,0.0001705177,0.0003927936,0.0001773665,0.0006617435,0.0007137239,0.00009363588],"category_scores_gemma":[0.00003022574,0.0007401376,0.0002450948,0.0002122631,0.000182733,0.00001133175,0.000932683,0.0006546137,0.00001612628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266701,"about_ca_system_score_gemma":0.0004872559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001802217,"about_ca_topic_score_gemma":0.00002512454,"domain_scores_codex":[0.9972124,0.0001073041,0.0005513313,0.001158532,0.0003753009,0.000595146],"domain_scores_gemma":[0.9979901,0.00001303865,0.0003311109,0.001144812,0.0001911943,0.0003297552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005521397,0.0001624464,0.01414894,0.0003154389,0.0001537261,0.0000287853,0.00001163623,0.00009639994,0.9844865,0.00005346737,0.0004826448,0.000004820405],"study_design_scores_gemma":[0.001062226,0.0003704808,0.01565397,0.00006373077,0.0001650566,9.536679e-8,0.00001157245,0.00008622195,0.8953428,0.000001377601,0.08602772,0.0012148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958292,0.001826732,0.0002882998,0.00004433965,0.0009546461,0.0005254319,0.0003127271,0.0001181185,0.0001004773],"genre_scores_gemma":[0.9967359,0.0005920883,0.001420917,0.0002267167,0.000612166,0.0001351658,0.000007781437,0.0001757932,0.00009347036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08914373,"threshold_uncertainty_score":0.999505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139149238226152,"score_gpt":0.216458694593282,"score_spread":0.2050672022110205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}