{"id":"W4292237130","doi":"10.3389/fnins.2022.917071","title":"Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo","year":2022,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Sunnybrook Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; University of Toronto; Canada Research Chairs","keywords":"Biology; Glial fibrillary acidic protein; mCherry; Cell biology; Astrocyte; Neuroscience; Green fluorescent protein; Immunology; Genetics; Central nervous system; Immunohistochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002002983,0.00009166832,0.0001226905,0.0001420855,0.000107676,0.00001026168,0.0004144338,0.00003328046,0.00002638555],"category_scores_gemma":[0.0002327561,0.0001048943,0.00004286242,0.0004887034,0.0002812729,0.00001015905,0.0003518034,0.0002387783,0.000001147936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004247003,"about_ca_system_score_gemma":0.0001254252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003150084,"about_ca_topic_score_gemma":0.000009299389,"domain_scores_codex":[0.9984452,0.0001676368,0.0002217882,0.0004547193,0.0004022708,0.0003083728],"domain_scores_gemma":[0.9995913,0.00001902478,0.00006522592,0.0002191215,0.00004075185,0.00006456556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001222277,0.0001200164,0.07621557,0.00001272789,8.328349e-7,0.00001868879,0.00004736707,0.002284067,0.9194688,0.00001211524,0.001600811,0.00009683592],"study_design_scores_gemma":[0.0005209598,0.0004495892,0.04165884,0.000007376428,0.000002195423,0.00000999822,0.0001670264,0.01270618,0.9393473,0.000009741228,0.004994424,0.0001263855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960589,0.0001084798,0.002717834,0.00009629601,0.0005616764,0.0001775261,0.00005088416,0.000004499165,0.0002238765],"genre_scores_gemma":[0.9983328,0.0001001735,0.0007817204,0.000230827,0.00001039726,0.0000325691,0.00001255895,0.000008832515,0.0004901521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03455672,"threshold_uncertainty_score":0.4277466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006771347126449719,"score_gpt":0.2465878903699504,"score_spread":0.2398165432435007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}