{"id":"W4292241648","doi":"10.1136/jitc-2022-004660","title":"Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Universitätsklinikum Hamburg-Eppendorf; Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Université Laval","keywords":"Adenosine; Cancer research; Ceritinib; Cancer cell; Pharmacology; Kinase; Chemistry; Adenosine kinase; Cancer; Medicine; Lung cancer; Biochemistry; Anaplastic lymphoma kinase; Adenosine deaminase; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516577,0.0003713704,0.0005301655,0.000282351,0.0001143589,0.0002402353,0.0002172312,0.0002758458,0.001508891],"category_scores_gemma":[0.0001286271,0.00006934472,0.0002796902,0.0002272842,0.0001192499,0.000158071,0.0001145723,0.00039426,0.0005764128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002439796,"about_ca_system_score_gemma":0.0002927676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002213748,"about_ca_topic_score_gemma":0.0006175251,"domain_scores_codex":[0.9998863,0.00001797305,0.00001142616,0.00002075804,0.00002995724,0.00003367917],"domain_scores_gemma":[0.9999422,0.00001035974,0.00001717676,0.000004454041,0.00001148711,0.00001436616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006758011,0.0002328107,0.0004537773,0.0003282641,0.00003326705,0.0002201794,0.00001290586,0.0004903944,0.9769639,0.0001849205,0.0006506384,0.01975306],"study_design_scores_gemma":[0.0003748196,0.004910943,0.00487054,0.00003771642,0.0001501815,0.002644039,0.00001742934,0.001618368,0.9638062,0.0001026694,0.02144859,0.00001843358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462944,0.03964415,0.005570441,0.0004685571,0.0002163195,0.0002407793,0.001038982,0.000236366,0.006290026],"genre_scores_gemma":[0.9811094,0.01018075,0.00382048,0.0001451596,0.00009449751,0.0001116995,0.001650561,0.00002897411,0.002858487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508891,"threshold_uncertainty_score":0.005047739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303813388304072,"score_gpt":0.301313983630451,"score_spread":0.2882758497474103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}