{"id":"W4292242254","doi":"10.1016/j.ccell.2022.07.011","title":"De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma","year":2022,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; Ludwig Center at Harvard; National Institutes of Health; National Institute of General Medical Sciences; Harvard Medical School; Sontag Foundation; EMD Serono; University of Texas Medical Branch; Howard Hughes Medical Institute; Cancer Prevention and Research Institute of Texas; V Foundation for Cancer Research; Dana-Farber Cancer Institute; Pharmaceuticals Bayer; Eli Lilly and Company","keywords":"Isocitrate dehydrogenase; Glioma; Dihydroorotate dehydrogenase; Mutant; Biology; Pyrimidine metabolism; IDH1; Cancer research; Enzyme; Biochemistry; Purine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008449332,0.0002484735,0.0002462399,0.0004189005,0.0001693224,0.0003107394,0.0002454086,0.0003240871,0.002007678],"category_scores_gemma":[0.0001689555,0.0001436025,0.0001808687,0.0001897797,0.0002262654,0.0002439721,0.0002327088,0.0003506565,0.0002722789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003124094,"about_ca_system_score_gemma":0.0001962077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001322618,"about_ca_topic_score_gemma":0.0009404428,"domain_scores_codex":[0.999928,0.000008385877,0.000008910907,0.00001358796,0.00002119124,0.00001984684],"domain_scores_gemma":[0.9999052,0.00001845578,0.00002438535,0.00001370302,0.00001137457,0.00002685242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003317825,0.0000213237,0.001570747,0.00002990294,0.00001085991,0.0009844722,0.00002725211,0.0001413603,0.9943895,0.0005695781,0.00007366531,0.001849522],"study_design_scores_gemma":[0.0000230667,0.0004228957,0.02206235,0.000003700682,0.00003476348,0.006918372,0.000136016,0.001165338,0.9665231,0.0005649947,0.002134913,0.00001051364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970146,0.0004561238,0.0009340653,0.00007964561,0.00001129123,0.000008667173,0.0003057071,0.00008491356,0.00110498],"genre_scores_gemma":[0.9990999,0.0001078905,0.0002065653,0.00001130997,0.000002318627,0.000004037634,0.0001070492,0.00000792511,0.0004532354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002007678,"threshold_uncertainty_score":0.006716311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347528264776997,"score_gpt":0.2776643383870762,"score_spread":0.2641890557393062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}