{"id":"W4292242254","doi":"10.1016/j.ccell.2022.07.011","title":"De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma","year":2022,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; Ludwig Center at Harvard; National Institutes of Health; National Institute of General Medical Sciences; Harvard Medical School; Sontag Foundation; EMD Serono; University of Texas Medical Branch; Howard Hughes Medical Institute; Cancer Prevention and Research Institute of Texas; V Foundation for Cancer Research; Dana-Farber Cancer Institute; Pharmaceuticals Bayer; Eli Lilly and Company","keywords":"Isocitrate dehydrogenase; Glioma; Dihydroorotate dehydrogenase; Mutant; Biology; Pyrimidine metabolism; IDH1; Cancer research; Enzyme; Biochemistry; Purine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003146812,0.0001250119,0.0001395175,0.00002981072,0.0001088397,0.00001528544,0.0002900296,0.00008415999,0.001846229],"category_scores_gemma":[0.00004929225,0.0001267905,0.00009144477,0.0001868643,0.00005989582,0.000002310637,0.000386289,0.0001943742,0.0000050248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678587,"about_ca_system_score_gemma":0.0002224248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006287706,"about_ca_topic_score_gemma":0.00007680916,"domain_scores_codex":[0.9986741,0.0001079089,0.0001556535,0.0004245579,0.0001862319,0.0004515374],"domain_scores_gemma":[0.9994695,0.00001289273,0.00003328321,0.0003344692,0.00003743773,0.0001123858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001445748,0.0001672206,0.001601702,0.00004370659,0.00001539331,0.00003082316,0.00004398093,0.000118273,0.9944284,0.000009359694,0.00228665,0.001109945],"study_design_scores_gemma":[0.0003330871,0.00007587203,0.0001279139,0.000004136878,0.00000817411,0.00001246645,0.0000725582,0.0001261332,0.9267355,0.00006877432,0.07228064,0.0001547616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909352,0.00536101,0.0001020193,0.0005011213,0.0000672669,0.0001764397,0.0001164662,0.000008557866,0.002731884],"genre_scores_gemma":[0.9976405,0.0002817574,0.0001198669,0.0007189423,0.00008162521,0.000420305,0.00003026344,0.00002304294,0.000683687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06999399,"threshold_uncertainty_score":0.9990662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347528264776997,"score_gpt":0.2776643383870762,"score_spread":0.2641890557393062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}