{"id":"W4292242368","doi":"10.1097/qad.0000000000003308","title":"Can simplified antiretroviral drug combination therapies resist resistance?","year":2022,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Vancouver Infectious Diseases Centre","funders":"","keywords":"Medicine; Regimen; Drug holiday; Viral load; Drug resistance; Clinical trial; Drug; Internal medicine; Antiretroviral therapy; HIV drug resistance; Human immunodeficiency virus (HIV); Intensive care medicine; Immunology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006369344,0.0008177937,0.00131389,0.0009172086,0.0005435919,0.003238242,0.001413965,0.003549133,0.02998593],"category_scores_gemma":[0.02603586,0.0003135973,0.0007814607,0.0008272207,0.003055427,0.00699334,0.002163445,0.005113326,0.007481714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001137515,"about_ca_system_score_gemma":0.001420321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001273886,"about_ca_topic_score_gemma":0.002106822,"domain_scores_codex":[0.9969439,0.001469731,0.0001800061,0.0003378698,0.0008779232,0.0001905927],"domain_scores_gemma":[0.9938981,0.003463174,0.0006969653,0.0005255371,0.0009404712,0.0004758355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008774941,0.0003429464,0.001169693,0.003087371,0.0002938873,0.0005080532,0.000519787,0.0008372477,0.0008671205,0.08350021,0.1568844,0.7511116],"study_design_scores_gemma":[0.0004782704,0.0009642872,0.001229932,0.002479795,0.000217707,0.0009491405,0.0003793892,0.0007785635,0.0006198096,0.1008157,0.8910333,0.00005416897],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.009474079,0.5128803,0.01059089,0.3877781,0.01318954,0.0002155476,0.0005967164,0.0004880386,0.06478694],"genre_scores_gemma":[0.1516222,0.5977634,0.01955761,0.178749,0.0257652,0.0005366582,0.0009262565,0.0002821366,0.02479745],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02998593,"threshold_uncertainty_score":0.1003129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068578319999192,"score_gpt":0.2436922286744856,"score_spread":0.2330064454744937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}