{"id":"W4292242368","doi":"10.1097/qad.0000000000003308","title":"Can simplified antiretroviral drug combination therapies resist resistance?","year":2022,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Vancouver Infectious Diseases Centre","funders":"","keywords":"Medicine; Regimen; Drug holiday; Viral load; Drug resistance; Clinical trial; Drug; Internal medicine; Antiretroviral therapy; HIV drug resistance; Human immunodeficiency virus (HIV); Intensive care medicine; Immunology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156554,0.0001249286,0.0002025759,0.0001346345,0.0003545439,0.0000184271,0.00008464107,0.00002014236,0.000431645],"category_scores_gemma":[0.00002025174,0.0001114525,0.00007059038,0.0003055621,0.00004314633,0.00004153105,0.00005892657,0.0001398875,0.00002707166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002398379,"about_ca_system_score_gemma":0.0001102635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004644328,"about_ca_topic_score_gemma":0.00003801411,"domain_scores_codex":[0.9989384,0.00007920372,0.0001832508,0.0002186839,0.0003777154,0.0002027934],"domain_scores_gemma":[0.9995581,0.00004646536,0.00005741376,0.0002335145,0.00004117222,0.00006335729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009802375,0.001161553,0.7262095,0.0001134906,0.0006432958,0.0003898405,0.01186385,0.00000259632,0.003245033,0.04199876,0.200511,0.0128808],"study_design_scores_gemma":[0.01462302,0.001471585,0.3258154,0.0001144361,0.0004657247,0.00004743199,0.01184237,0.00004755209,0.01110389,0.01187367,0.6216774,0.0009175565],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968843,0.000519993,0.0000076725,0.01453268,0.0001936855,0.0003255985,0.00002442845,0.0001176092,0.01543532],"genre_scores_gemma":[0.8342541,0.00002156163,0.0004960677,0.0004038326,0.00003452884,0.00007560443,0.0001817733,0.00001851647,0.164514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4211664,"threshold_uncertainty_score":0.472621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068578319999192,"score_gpt":0.2436922286744856,"score_spread":0.2330064454744937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}