{"id":"W4292249170","doi":"10.1093/eurheartj/ehac460","title":"A polygenic risk score predicts atrial fibrillation in cardiovascular disease","year":2022,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Idorsia Pharmaceuticals; Servier; Assistance publique-Hôpitaux de Paris; Duke Clinical Research Institute; Eisai; Daiichi-Sankyo; Bayer HealthCare; Zora Biosciences; Belvoir Media Group; Novo Nordisk; MyoKardia; AstraZeneca; Amarin Corporation; Ironwood Pharmaceuticals, Incorporated; National Institutes of Health; Regeneron Pharmaceuticals; Brigham and Women's Hospital; Boston VA Research Institute; Boston Scientific Corporation; Alnylam Pharmaceuticals; Regado Biosciences; Medicines Company; American Heart Association; Intarcia Therapeutics; Teva Pharmaceutical Industries; Bristol-Myers Squibb; Cleveland Clinic; Moderna; Innovent Biologics; Pfizer; Biogen; HLS Therapeutics; GlaxoSmithKline; CSL Behring; Eli Lilly and Company; Amgen; St. Jude Medical; Kowa Company; Sanofi","keywords":"Medicine; Atrial fibrillation; Internal medicine; Cardiology; Polygenic risk score; Framingham Risk Score; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00126865,0.0005559656,0.0002937549,0.0008413683,0.0002760771,0.0006236468,0.0002589624,0.0005980417,0.001876578],"category_scores_gemma":[0.004449047,0.0001687185,0.0006303336,0.0007108166,0.0003678107,0.0003495647,0.0005577108,0.0006344764,0.0003350715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001405342,"about_ca_system_score_gemma":0.0002592232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001814046,"about_ca_topic_score_gemma":0.0017681,"domain_scores_codex":[0.9994191,0.0002733668,0.00005134735,0.0001054108,0.00009577454,0.00005504975],"domain_scores_gemma":[0.99734,0.0008834488,0.001014662,0.0002386692,0.0001594739,0.0003637386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001195463,0.00002770776,0.9961503,0.000007476457,0.000155348,0.00005285626,0.00001030448,0.0003331075,0.0002686844,0.00004754113,0.0001010616,0.00272614],"study_design_scores_gemma":[0.00000860709,0.0001134684,0.9962264,0.000005194689,0.0000794251,0.0002854303,0.00001152756,0.002883508,0.00005223395,0.0002270894,0.0001025247,0.000004601432],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963765,0.0006420698,0.001370567,0.0002829088,0.00001815987,0.00001563744,0.0003462282,0.00002797391,0.0009199419],"genre_scores_gemma":[0.9990475,0.00009580669,0.0004175862,0.00003031022,0.00002608239,0.000003863249,0.0002740815,0.000002249596,0.0001025491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876578,"threshold_uncertainty_score":0.006709397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06814889831310732,"score_gpt":0.3011489420312345,"score_spread":0.2330000437181272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}