{"id":"W4292249170","doi":"10.1093/eurheartj/ehac460","title":"A polygenic risk score predicts atrial fibrillation in cardiovascular disease","year":2022,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Idorsia Pharmaceuticals; Servier; Assistance publique-Hôpitaux de Paris; Duke Clinical Research Institute; Eisai; Daiichi-Sankyo; Bayer HealthCare; Zora Biosciences; Belvoir Media Group; Novo Nordisk; MyoKardia; AstraZeneca; Amarin Corporation; Ironwood Pharmaceuticals, Incorporated; National Institutes of Health; Regeneron Pharmaceuticals; Brigham and Women's Hospital; Boston VA Research Institute; Boston Scientific Corporation; Alnylam Pharmaceuticals; Regado Biosciences; Medicines Company; American Heart Association; Intarcia Therapeutics; Teva Pharmaceutical Industries; Bristol-Myers Squibb; Cleveland Clinic; Moderna; Innovent Biologics; Pfizer; Biogen; HLS Therapeutics; GlaxoSmithKline; CSL Behring; Eli Lilly and Company; Amgen; St. Jude Medical; Kowa Company; Sanofi","keywords":"Medicine; Atrial fibrillation; Internal medicine; Cardiology; Polygenic risk score; Framingham Risk Score; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001878645,0.000119681,0.0002770233,0.0002825718,0.0003693829,0.00005024587,0.00007764538,0.00001180014,0.0004680297],"category_scores_gemma":[0.0003188194,0.0001118907,0.0008381821,0.0003295588,0.00001993733,0.0001191536,0.0001420892,0.0004045448,0.00008271727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001330974,"about_ca_system_score_gemma":0.0001024234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009986172,"about_ca_topic_score_gemma":5.079251e-7,"domain_scores_codex":[0.9975424,0.0009453631,0.0003618954,0.0002107351,0.0007069678,0.0002325765],"domain_scores_gemma":[0.9992717,0.00005350552,0.0001182393,0.0002813172,0.00003187135,0.0002433507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006581452,0.000002991256,0.9508219,0.00001094393,0.0002391782,0.0004021638,0.0001228678,0.03970793,0.00001690131,0.00001738533,0.002035653,0.005963922],"study_design_scores_gemma":[0.002417289,0.0001295083,0.758516,0.00002095237,0.000271362,0.0001792747,0.00005110539,0.001160849,7.224927e-7,0.00003299286,0.2371322,0.00008776832],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894317,0.006084172,0.0001363689,0.001631101,0.0009440554,0.00042411,0.00001237078,0.00005886432,0.001277225],"genre_scores_gemma":[0.9928175,0.0003221499,0.000164326,0.0001230003,0.005642345,3.152417e-7,0.00002114673,0.00003716354,0.0008720165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2350966,"threshold_uncertainty_score":0.5124597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06814889831310732,"score_gpt":0.3011489420312345,"score_spread":0.2330000437181272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}